CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007004
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proteasome-interacting protein CIC1 
Protein Synonyms/Alias
 Core interacting component 1 
Gene Name
 CIC1 
Gene Synonyms/Alias
 NSA3; YHR052W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
39IPRERVIKAVNELIKacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 An adapter protein that specifically links the 26S proteasome to its substrate CDC4 which is one of the substrate recognition subunits of the SCF E3 ubiquitin ligase complex. Required for turnover of cell cycle regulatory proteins CDC4 and GRR1. Required for synthesis and nuclear export of 60S ribosomal subunits. Required for vegetative growth. 
Sequence Annotation
 REGION 310 376 Required for interaction with CDC4.  
Keyword
 Complete proteome; Nucleus; Proteasome; Reference proteome; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MAKKSNSKKS TPVSTPSKEK KKVIEKKSST AIPRERVIKA VNELIKFTSK PQDENNEEGN 60
NGKKNLLEDD EEELKKDLQL IVVNNKSFTG TSKSFKLKLL NVKHSFYKPW KEASATAVKD 120
FKVLLILKDS DIKKVSEDDL FDQLDSEGIK VDEIICGKDL KTVYKAYEAR NAFISQFSLI 180
LADDSIVTSL PKLMGGKAYN KVETTPISIR THANKEFSLT TLTNNIKKVY MNQLPVKLPR 240
GTTLNVHLGN LEWLRPEEFV DNVELISEQL IKAYQIRSIF IKTNRSPVLP LYYNQDVLDE 300
LEAKKDKIEE THEDDMVTID GVQVHLSTFN KGLMEIANPS ELGSIFSKQI NNAKKRSSSE 360
LEKESSESEA VKKAKS 376 
Gene Ontology
 GO:0015934; C:large ribosomal subunit; IEA:InterPro.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0030687; C:preribosome, large subunit precursor; IDA:SGD.
 GO:0000502; C:proteasome complex; IPI:SGD.
 GO:0030674; F:protein binding, bridging; IMP:SGD.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0030163; P:protein catabolic process; IMP:SGD.
 GO:0042273; P:ribosomal large subunit biogenesis; IPI:SGD.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR002143; Ribosomal_L1.
 IPR023674; Ribosomal_L1_SF. 
Pfam
 PF00687; Ribosomal_L1 
SMART
  
PROSITE
  
PRINTS