CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-028495
UniProt Accession
A2A7Q5_MOUSE
;
A2A7Q5
Genbank Protein ID
AL606975
Genbank Nucleotide ID
Protein Name
Prolyl 3-hydroxylase 1
Protein Synonyms/Alias
Gene Name
Lepre1
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Lysine Modification
Position
Peptide
Type
References
523
FYGVTVL
K
ALKLGQE
acetylation
[1]
Reference
[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [
PMID: 22826441
]
Functional Description
Sequence Annotation
Keyword
Complete proteome; Reference proteome.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
748 AA
Protein Sequence
MAVSERRLLA AMLAVAAAAA LRVAAESEPG WDVAAPDLLY AEGTAAYSRG DWPGVVLNME 60
RALRSRAALR ALRLRCRTRC ATELPWAPDL DLGPDPSLSQ DPGAAALHDL RFFGAVLRRA 120
ACLRRCLGPP SAHLLSEELD LEFNKRSPYN YLQVAYFKIN KLEKAVAAAH TFFVGNPEHM 180
EMRQNLDYYQ TMSGVKEADF RDLEAKPHMH EFRLGVRLYS EEKPQEAVPH LEAALQEYFV 240
ADEECRALCE GPYDYDGYNY LDYSADLFQA ITDHYVQVLN CKQNCVTELA SHPSREKPFE 300
DFLPSHYNYL QFAYYNIGNY TQAIECAKTY LLFFPNDEVM HQNLAYYTAM LGEEEASSIS 360
PRENAEEYRR RSLLEKELLF FAYDIFGIPF VDPDSWTPEE VIPKRLQEKQ KSERETAVRI 420
SQEIGNLMKE IETLVEEKTK ESLDVSRLTR EGGPLLYEGI SLTMNSKVLN GSQRVVMDGV 480
ISDDECQELQ RLTNAAATSG DGYRGQTSPH TPNEKFYGVT VLKALKLGQE GKVPLQSARM 540
YYNVTEKVRR VMESYFRLDT PLYFSYSHLV CRTAIEESQA ERKDSSHPVH VDNCILNAEA 600
LMCIKEPPAY TFRDYSAILY LNGDFDGGNF YFTELDAKTV TAEVQPQCGR AVGFSSGTEN 660
PHGVKAVTRG QRCAIALWFT LDPRHSERDR VQADDLVKML FSPEEVDLPQ EQPLPDQQGS 720
PEPGEDLLHG ATVLGVGIAG HTLLWAWL 748
Gene Ontology
GO:0005783
; C:endoplasmic reticulum; ISO:MGI.
GO:0005634
; C:nucleus; IDA:MGI.
GO:0005886
; C:plasma membrane; TAS:MGI.
GO:0005506
; F:iron ion binding; IEA:InterPro.
GO:0031418
; F:L-ascorbic acid binding; IEA:InterPro.
GO:0019797
; F:procollagen-proline 3-dioxygenase activity; ISO:MGI.
GO:0016049
; P:cell growth; IDA:MGI.
GO:0030199
; P:collagen fibril organization; IMP:MGI.
GO:0032963
; P:collagen metabolic process; ISO:MGI.
GO:0030278
; P:regulation of ossification; IMP:MGI.
Interpro
IPR005123
; Oxoglu/Fe-dep_dioxygenase.
IPR006620
; Pro_4_hyd_alph.
IPR011990
; TPR-like_helical.
Pfam
PF13640
; 2OG-FeII_Oxy_3
SMART
SM00702
; P4Hc
PROSITE
PS51471
; FE2OG_OXY
PRINTS