CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023127
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein CDV3 homolog 
Protein Synonyms/Alias
  
Gene Name
 CDV3 
Gene Synonyms/Alias
 H41 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15SLDNFFAKRDKKKKKacetylation[1, 2, 3]
80AATKAVTKDEDEWKEacetylation[3, 4]
251YAVLENQKSSHSQYNubiquitination[5]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 4 4 Phosphothreonine (By similarity).
 MOD_RES 8 8 Phosphoserine (By similarity).
 MOD_RES 95 95 Phosphotyrosine (By similarity).
 MOD_RES 107 107 Phosphoserine.
 MOD_RES 182 182 Phosphothreonine.
 MOD_RES 190 190 Phosphotyrosine (By similarity).
 MOD_RES 244 244 Phosphotyrosine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MAETEERSLD NFFAKRDKKK KKERSNRAAS AAGAAGSAGG SSGAAGAAGG GAGAGTRPGD 60
GGTASAGAAG PGAATKAVTK DEDEWKELEQ KEVDYSGLRV QAMQISSEKE EDDNEKRQDP 120
GDNWEEGGGG GGGMEKSSGP WNKTAPVQAP PAPVIVTETP EPAMTSGVYR PPGARLTTTR 180
KTPQGPPEIY SDTQFPSLQS TAKHVESRKD KEMEKSFEVV RHKNRGRDEV SKNQALKLQL 240
DNQYAVLENQ KSSHSQYN 258 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0008283; P:cell proliferation; NAS:UniProtKB. 
Interpro
 IPR026806; CDV3. 
Pfam
  
SMART
  
PROSITE
  
PRINTS