UniProt Accession

 ATTY_HUMAN; P17735; B2R8I1; D3DWS2 

Genbank Protein ID

 X52520; X52509; X52510; X52511; X52512; X52513; X52514; X52515; X52516; X52517; X52518; X52519; X55675; AK313380; CH471166; CH471166 

Genbank Nucleotide ID

 CAA36750.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA36749.1; CAA39210.1; BAG36178.1; EAW59230.1; EAW59231.1 

Protein Name

 Tyrosine aminotransferase 

Protein Synonyms/Alias

 TAT; L-tyrosine:2-oxoglutarate aminotransferase 

Gene Name

 TAT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	GRSSVPGKMKGRKAR	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 280 280 N6-(pyridoxal phosphate)lysine.  

Keyword

 3D-structure; Acetylation; Aminotransferase; Complete proteome; Disease mutation; Mental retardation; Palmoplantar keratoderma; Phenylalanine catabolism; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase; Tyrosine catabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 454 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:EC.
 GO:0004838; F:L-tyrosine:2-oxoglutarate aminotransferase activity; IDA:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006103; P:2-oxoglutarate metabolic process; IDA:UniProtKB.
 GO:0009058; P:biosynthetic process; IEA:InterPro.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006536; P:glutamate metabolic process; IDA:UniProtKB.
 GO:0006559; P:L-phenylalanine catabolic process; NAS:UniProtKB.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0046689; P:response to mercury ion; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0006572; P:tyrosine catabolic process; IDA:UniProtKB. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR004838; NHTrfase_class1_PyrdxlP-BS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR011715; Tyr_aminoTrfase_ubiquitination.
 IPR005958; TyrNic_aminoTrfase.
 IPR005957; Tyrosine_aminoTrfase.
 IPR021178; Tyrosine_transaminase. 

Pfam

 PF00155; Aminotran_1_2
 PF07706; TAT_ubiq 

SMART

  

PROSITE

 PS00105; AA_TRANSFER_CLASS_1 

PRINTS