CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038339
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 
Protein Synonyms/Alias
  
Gene Name
 Cacna1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1851DLLVTPHKSTDLTVGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Calcium channel; Calcium transport; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2321 AA 
Protein Sequence
MARFGDEMPG RYGAGGGGSG PAAGVVVGAA GGRGAGGSRQ GGQPGAQRMY KQSMAQRART 60
MALYNPIPVR QNCLTVNRSL FLFSEDNVDD TEPYFIGIFC FEAGIKIVAL GFAFHKGSYL 120
RNGWNVMDFV VVLTGILATV GTEFDLRTLR AVRVLRPLKL VSGIPSLQVV LKSIMKAMIP 180
LLQIGLLLFF AILIFAIIGL EFYMGKFHTT CFEEGTDDIQ GESPAPCGTE EPARTCPNGT 240
KCQPYWEGPN NGITQFDNIL FAVLTVFQCI TMEGWTDLLY NSNDASGNTW NWLYFIPLII 300
IGSFFMLNLV LGVLSGEFAK ERERVENRRA FLKLRRQQQI ERELNGYMEW ISKAEEVILA 360
EDETDVEQRH PFDGALRRAT LKKSKTDLLN PEEAEDQLAD IASVGSPFAR ASIKSAKLEN 420
STFFHKKERR MRFYIRRMVK TQAFYWTVLS LVALNTLCVA IVHYNQPEWL SDFLYYAEFI 480
FLGLFMSEMF IKMYGLGTRP YFHSSFNCFD CGVIIGSIFE VIWAVIKPGT SFGISVLRAL 540
RLLRIFKVTK YWASLRNLVV SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFDEG 600
TPPTNFDTFP AAIMTVFQIL TGEDWNEVMY DGIKSQGGVQ GGMVFSIYFI VLTLFGNYTL 660
LNVFLAIAVD NLANAQELTK DEQEEEEAAN QKLALQKAKE VAEVSPLSAA NMSIAVKEQQ 720
KNQKPTKSVW EQRTSEMRKQ NLLASREALY GDAAERWPTP YARPLRPDVK THLDRPLVVD 780
PQENRNNNTN KSRAPEALRP TARPRESARD PDARRAWPGS PERAPGREGP YGRESEPQQR 840
EHAPPREHAP WDADTERAKA GDAPRRHTHR PVAEGEPRRH RARRRPGDEP DDRPERRPRP 900
RDATRPARAA DGEGDDGERK RRHRHGPPAH DDRERRHRRR KENQGSGVPV SGPNLSTTRP 960
IQQDLGRQDL PLAEDLDNMK NNKLATGEPA SPHDSLGHSG LPPSPAKIGN STNPGPALAT 1020
NPQNAASRRT PNNPGNPSNP GPPKTPENSL IVTNPSSTQP NSAKTARKPE HMAVEIPPAC 1080
PPLNHTVVQV NKNANPDPLP KKEEEKKEEE EADPGEDGPK PMPPYSSMFI LSTTNPLRRL 1140
CHYILNLRYF EMCILMVIAM SSIALAAEDP VQPNAPRNNV LRYFDYVFTG VFTFEMVIKM 1200
IDLGLVLHQG AYFRDLWNIL DFIVVSGALV AFAFTGNSKG KDINTIKSLR VLRVLRPLKT 1260
IKRLPKLKAV FDCVVNSLKN VFNILIVYML FMFIFAVVAV QLFKGKFFHC TDESKEFERD 1320
CRGKYLLYEK NEVKARDREW KKYEFHYDNV LWALLTLFTV STGEGWPQVL KHSVDATFEN 1380
QGPSPGYRME MSIFYVVYFV VFPFFFVNIF VALIIITFQE QGDKMMEEYS LEKNERACID 1440
FAISAKPLTR HMPQNKQSFQ YRMWQFVVSP PFEYTIMAMI ALNTIVLMMK FYGASVAYEN 1500
ALRVFNIVFT SLFSLECVLK VMAFGILNYF RDAWNIFDFV TVLGSITDIL VTEFGNNFIN 1560
LSFLRLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC LLIAMLFFIY AIIGMQVFGN 1620
IGIDGEDEDS DEDEFQITEH NNFRTFFQAL MLLFRSATGE AWHNIMLSCL SGKPCDKNSG 1680
ILTADCGNEF AYFYFVSFIF LCSFLMLNLF VAVIMDNFEY LTRDSSILGP HHLDEYVRVW 1740
AEYDPAACGR IHYKDMYSLL RVISPPLGLG KKCPHRVACK RLLRMDLPVA DDNTVHFNST 1800
LMALIRTALD IKIAKGGADK QQMDAELRKE MMAIWPNLSQ KTLDLLVTPH KSTDLTVGKI 1860
YAAMMIMEYY RQSKAKKLQA MREEQNRTPL MFQRMEPPSP TQEGGPSQNA LPSTQLDPGG 1920
GLMAHEGGMK ESPSWVTQRA QEMFQKTGTW SPERGPPIDM PNSQPNSQSV EMREMGTDGY 1980
SDSEHYLPME GQTRAASMPR LPAENQRRRG RPRGNDLSTI SDTSPMKRSA SVLGPKARRL 2040
DDYSLERVPP EENQRYHQRR RDRGHRTSER SLGRYTDVDT GLGTDLSMTT QSGDLPSKDR 2100
DQDRGRPKDR KHRPHHHHHH HHHHPPAPDR DRYAQERPDT GRARAREQRW SRSPSEGREH 2160
TTHRQGSSSV SGSPAPSTSG TSTPRRGRRQ LPQTPCTPRP LVSYSPAPRR PAARRMAGPA 2220
APPGGSPRGC RRAPRWPAHA PEGPRPRGAD YTEPDSPREP PGGAHDPAPR SPRTPRAAGC 2280
ASPRHGRRLP NGYYAGHGAP RPRTARRGAH DAYSESEDDW C 2321 
Gene Ontology
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005891; C:voltage-gated calcium channel complex; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008331; F:high voltage-gated calcium channel activity; IMP:MGI.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0048266; P:behavioral response to pain; IMP:MGI.
 GO:0017156; P:calcium ion-dependent exocytosis; IMP:MGI.
 GO:0048791; P:calcium ion-dependent exocytosis of neurotransmitter; IMP:MGI.
 GO:0016049; P:cell growth; IMP:MGI.
 GO:0030644; P:cellular chloride ion homeostasis; IMP:MGI.
 GO:0021679; P:cerebellar molecular layer development; IMP:MGI.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
 GO:0021590; P:cerebellum maturation; IMP:MGI.
 GO:0048813; P:dendrite morphogenesis; IMP:MGI.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IDA:MGI.
 GO:0014051; P:gamma-aminobutyric acid secretion; IMP:MGI.
 GO:0007214; P:gamma-aminobutyric acid signaling pathway; IMP:MGI.
 GO:0006006; P:glucose metabolic process; IMP:MGI.
 GO:0042445; P:hormone metabolic process; IMP:MGI.
 GO:0051899; P:membrane depolarization; IMP:MGI.
 GO:0050883; P:musculoskeletal movement, spinal reflex action; IMP:MGI.
 GO:0032353; P:negative regulation of hormone biosynthetic process; IMP:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI.
 GO:0042133; P:neurotransmitter metabolic process; IMP:MGI.
 GO:0043113; P:receptor clustering; IMP:MGI.
 GO:0014056; P:regulation of acetylcholine secretion; IMP:MGI.
 GO:0050770; P:regulation of axonogenesis; IMP:MGI.
 GO:0017158; P:regulation of calcium ion-dependent exocytosis; IDA:MGI.
 GO:0060024; P:rhythmic synaptic transmission; IMP:MGI.
 GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
 GO:0000096; P:sulfur amino acid metabolic process; IMP:MGI.
 GO:0007416; P:synapse assembly; IMP:MGI.
 GO:0035249; P:synaptic transmission, glutamatergic; IMP:MGI.
 GO:0021750; P:vestibular nucleus development; IMP:MGI. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR014873; VDCC_a1su_IQ.
 IPR005448; VDCC_P/Q_a1su.
 IPR002077; VDCCAlpha1. 
Pfam
 PF08763; Ca_chan_IQ
 PF00520; Ion_trans 
SMART
 SM00384; AT_hook
 SM01062; Ca_chan_IQ 
PROSITE
  
PRINTS
 PR00167; CACHANNEL.
 PR01632; PQVDCCALPHA1.