CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007551
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Longitudinals lacking protein, isoform G 
Protein Synonyms/Alias
  
Gene Name
 lola 
Gene Synonyms/Alias
 CG12052 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
138SGHHRGGKLSGAYTLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo. 
Sequence Annotation
 DOMAIN 32 97 BTB.
 ZN_FING 791 813 C2H2-type 1; degenerate.
 ZN_FING 821 843 C2H2-type 2.
 MOD_RES 140 140 Phosphoserine.
 MOD_RES 161 161 Phosphothreonine.
 MOD_RES 162 162 Phosphoserine.
 MOD_RES 168 168 Phosphoserine.
 MOD_RES 372 372 Phosphoserine.
 MOD_RES 375 375 Phosphoserine.
 MOD_RES 378 378 Phosphoserine.
 MOD_RES 696 696 Phosphoserine.
 MOD_RES 705 705 Phosphoserine.
 MOD_RES 706 706 Phosphothreonine.
 MOD_RES 749 749 Phosphoserine.
 MOD_RES 750 750 Phosphoserine.
 MOD_RES 874 874 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; Differentiation; DNA-binding; Metal-binding; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 891 AA 
Protein Sequence
MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL 60
LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR 180
KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS 240
STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN 300
VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS 360
SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ 420
GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQDLSRKE NTAPDVASTA EIQRSFQRSI 480
LNGKQRDEQK IQLPGSRRKR LSVTEVSDML FEFYKTKSAK VPKAEQPHRQ VSPTSGEILD 540
PSTISAIAVY GTASETASKN LNADEVMRVQ NATATRVVGA AAGAAASFHP RPKYTLKTAA 600
SSTEHTTAIP TSVLVANSAA ALTPKPQAAV IAEALMRNGL HNFQQQLRAQ EILRQQTPHR 660
RIKEENDVEI AGGDITPTKI LENLLRKQQE RDLRHSECEN EPGYSTEDDE EGRYHAFDDI 720
HLMEQSGGKF GNNSGMGMFN ANAHGGSASS ILDAHQAFRN LEFTLSDYGG SSSNGSTTSP 780
NGIGLDGEPV YECRHCGKKY RWKSTLRRHE NVECGGKEPS HQCPYCPYKS KQRGNLGVHV 840
RKHHTDLPQL PSKRRSKYSM NRENGMSGSM SDDSQGKLII DFNGKGELET K 891 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0019730; P:antimicrobial humoral response; IMP:FlyBase.
 GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.
 GO:0048854; P:brain morphogenesis; IMP:FlyBase.
 GO:0008406; P:gonad development; IMP:FlyBase.
 GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase.
 GO:0031987; P:locomotion involved in locomotory behavior; IMP:FlyBase.
 GO:0045476; P:nurse cell apoptotic process; IMP:FlyBase.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0007464; P:R3/R4 cell fate commitment; IMP:FlyBase.
 GO:0045467; P:R7 cell development; IMP:FlyBase.
 GO:0001964; P:startle response; IMP:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB
 PF00096; zf-C2H2 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS