| Tag | Content |
|---|
| CPLM ID | CPLM-024146 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein fem-1 homolog B |
Protein Synonyms/Alias | FEM1b; FEM1-beta; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; F1A-alpha; mt-Fem |
Gene Name | Fem1b |
Gene Synonyms/Alias | F1aa; Kiaa0396 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 598 | TQMKMSLKCLAARAV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity). |
Sequence Annotation | REPEAT 45 74 ANK 1.
REPEAT 87 116 ANK 2.
REPEAT 120 149 ANK 3.
REPEAT 153 182 ANK 4.
REPEAT 186 215 ANK 5.
REPEAT 218 248 ANK 6.
REPEAT 344 377 TPR.
REPEAT 483 527 ANK 7.
REPEAT 531 568 ANK 8. |
Keyword | ANK repeat; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 627 AA |
Protein Sequence | MEGLAGYVYK AASEGKVLTL AALLLNRSES DIRYLLGYVS QQGGQRSTPL IIAARNGHAK 60
VVRLLLEHYR VQTQQTGTVR FDGYVIDGAT ALWCAAGAGH FEVVKLLVSH GANVNHTTVT 120
NSTPLRAACF DGRLDIVKYL VENNANISIA NKYDNTCLMI AAYKGHTDVV RYLLEQRADP 180
NAKAHCGATA LHFAAEAGHI DIVKELIKWR AAIVVNGHGM TPLKVAAESC KADVVELLLS 240
HADCDRRSRI EALELLGASF ANDRENYDIM KTYHYLYLAM LERFQDGDNI LEKEVLPPIH 300
AYGNRTECRN PQELEAIRQD RDALHMEGLI VRERILGADN IDVSHPIIYR GAVYADNMEF 360
EQCIKLWLHA LHLRQKGNRN THKDLLRFAQ VFSQMIHLNE AVKAPDIECV LRCSVLEIEQ 420
SMNRVKNISD ADVHSAMDNY ECNLYTFLYL VCISTKTQCS EEDQCRINKQ IYNLIHLDPR 480
TREGFSLLHL AVNSNTPVDD FHTNDVCSFP NALVTKLLLD CGAEVNAVDN EGNSALHIIV 540
QYNRPISDFL TLHSIIISLV EAGAHTDMTN KQNKTPLDKS TTGVSEILLK TQMKMSLKCL 600
AARAVRANDI NYQDQIPRTL EEFVGFH 627 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0060442; P:branching involved in prostate gland morphogenesis; IMP:MGI. GO:0060743; P:epithelial cell maturation involved in prostate gland development; IMP:MGI. GO:0016567; P:protein ubiquitination; IDA:MGI. GO:0042981; P:regulation of apoptotic process; IEA:Compara. GO:2000001; P:regulation of DNA damage checkpoint; ISS:UniProtKB. GO:0051438; P:regulation of ubiquitin-protein ligase activity; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |