CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008307
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal targeting signal 1 receptor 
Protein Synonyms/Alias
 PTS1 receptor; PTS1R; PTS1-BP; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1 
Gene Name
 PEX5 
Gene Synonyms/Alias
 PXR1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
419GAGLGPSKRILGSLLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. 
Sequence Annotation
 REPEAT 335 368 TPR 1.
 REPEAT 369 402 TPR 2.
 REPEAT 403 436 TPR 3.
 REPEAT 452 485 TPR 4.
 REPEAT 488 521 TPR 5.
 REPEAT 522 555 TPR 6.
 REPEAT 556 589 TPR 7.
 CROSSLNK 11 11 Glycyl cysteine thioester (Cys-Gly)  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Membrane; Peroxisome; Peroxisome biogenesis disorder; Protein transport; Reference proteome; Repeat; Thioester bond; TPR repeat; Transport; Ubl conjugation; Zellweger syndrome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 639 AA 
Protein Sequence
MAMRELVEAE CGGANPLMKL AGHFTQDKAL RQEGLRPGPW PPGAPASEAA SKPLGVASED 60
ELVAEFLQDQ NAPLVSRAPQ TFKMDDLLAE MQQIEQSNFR QAPQRAPGVA DLALSENWAQ 120
EFLAAGDAVD VTQDYNETDW SQEFISEVTD PLSVSPARWA EEYLEQSEEK LWLGEPEGTA 180
TDRWYDEYHP EEDLQHTASD FVAKVDDPKL ANSEGTSDAW VDQFTRPVNT SALDMEFERA 240
KSAIESDVDF WDKLQAELEE MAKRDAEAHP WLSDYDDLTS ATYDKGYQFE EENPLRDHPQ 300
PFEEGLRRLQ EGDLPNAVLL FEAAVQQDPK HMEAWQYLGT TQAENEQELL AISALRRCLE 360
LKPDNQTALM ALAVSFTNES LQRQACETLR DWLRYTPAYA HLVTPAEEGA GGAGLGPSKR 420
ILGSLLSDSL FLEVKELFLA AVRLDPTSID PDVQCGLGVL FNLSGEYDKA VDCFTAALSV 480
RPNDYLLWNK LGATLANGNQ SEEAVAAYRR ALELQPGYIR SRYNLGISCI NLGAHREAVE 540
HFLEALNMQR KSRGPRGEGG AMSENIWSTL RLALSMLGQS DAYGAADARD LSTLLTMFGL 600
PQ 602 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005782; C:peroxisomal matrix; IDA:UniProtKB.
 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0005052; F:peroxisome matrix targeting signal-1 binding; IDA:UniProtKB.
 GO:0048468; P:cell development; IEA:Compara.
 GO:0021795; P:cerebral cortex cell migration; IEA:Compara.
 GO:0021895; P:cerebral cortex neuron differentiation; IEA:Compara.
 GO:0007029; P:endoplasmic reticulum organization; IEA:Compara.
 GO:0006635; P:fatty acid beta-oxidation; IEA:Compara.
 GO:0007006; P:mitochondrial membrane organization; IEA:Compara.
 GO:1901094; P:negative regulation of protein homotetramerization; IDA:UniProtKB.
 GO:0050905; P:neuromuscular process; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0016558; P:protein import into peroxisome matrix; IGI:UniProtKB.
 GO:0016560; P:protein import into peroxisome matrix, docking; IDA:UniProtKB.
 GO:0016561; P:protein import into peroxisome matrix, translocation; IDA:UniProtKB.
 GO:0045046; P:protein import into peroxisome membrane; IMP:UniProtKB.
 GO:0051262; P:protein tetramerization; IDA:UniProtKB.
 GO:0000038; P:very long-chain fatty acid metabolic process; IEA:Compara. 
Interpro
 IPR024111; PTS1R_family.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS