CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004733
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Androgen receptor 
Protein Synonyms/Alias
 Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4 
Gene Name
 Ar 
Gene Synonyms/Alias
 Nr3c4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
700VHVVKWAKALPGFRNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity). 
Sequence Annotation
 DNA_BIND 538 611 Nuclear receptor.
 ZN_FING 539 559 NR C4-type.
 ZN_FING 575 599 NR C4-type.
 REGION 1 537 Modulating (By similarity).
 REGION 531 899 Interaction with LPXN (By similarity).
 REGION 551 641 Interaction with HIPK3 (By similarity).
 REGION 604 899 Interaction with KAT7 (By similarity).
 REGION 670 899 Ligand-binding.
 BINDING 685 685 Androgen.
 BINDING 732 732 Androgen.
 BINDING 857 857 Androgen.
 MOD_RES 61 61 Phosphoserine; by CDK9 (By similarity).
 MOD_RES 75 75 Phosphoserine (By similarity).
 MOD_RES 218 218 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 262 262 Phosphotyrosine; by CSK and TNK2 (By
 MOD_RES 302 302 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 341 341 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 352 352 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 357 357 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 358 358 Phosphotyrosine; by CSK and TNK2 (By
 MOD_RES 388 388 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 514 514 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 531 531 Phosphotyrosine; by CSK (By similarity).
 MOD_RES 630 630 Phosphoserine; by STK4/MST1 (By
 MOD_RES 895 895 Phosphotyrosine; by CSK (By similarity).
 CROSSLNK 381 381 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 500 500 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 825 825 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 827 827 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Complete proteome; Cytoplasm; DNA-binding; Isopeptide bond; Lipid-binding; Lipoprotein; Metal-binding; Nucleus; Palmitate; Phosphoprotein; Receptor; Reference proteome; Steroid-binding; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 899 AA 
Protein Sequence
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REAIQNPGPR HPEAANIAPP GACLQQRQET 60
SPRRRRRQQH TEDGSPQAHI RGPTGYLALE EEQQPSQQQA ASEGHPESSC LPEPGAATAP 120
GKGLPQQPPA PPDQDDSAAP STLSLLGPTF PGLSSCSADI KDILNEAGTM QLLQQQQQQQ 180
QHQQQHQQHQ QQQEVISEGS SARAREATGA PSSSKDSYLG GNSTISDSAK ELCKAVSVSM 240
GLGVEALEHL SPGEQLRGDC MYASLLGGPP AVRPTPCAPL PECKGLPLDE GPGKSTEETA 300
EYSSFKGGYA KGLEGESLGC SGSSEAGSSG TLEIPSSLSL YKSGALDEAA AYQNRDYYNF 360
PLALSGPPHP PPPTHPHARI KLENPLDYGS AWAAAAAQCR YGDLGSLHGG SVAGPSTGSP 420
PATTSSSWHT LFTAEEGQLY GPGGGGGSSS PSDAGPVAPY GYTRPPQGLT SQESDYSASE 480
VWYPGGVVNR VPYPSPNCVK SEMGPWMENY SGPYGDMRLD STRDHVLPID YYFPPQKTCL 540
ICGDEASGCH YGALTCGSCK VFFKRAAEGK QKYLCASRND CTIDKFRRKN CPSCRLRKCY 600
EAGMTLGARK LKKLGNLKLQ EEGENSNAGS PTEDPSQKMT VSHIEGYECQ PIFLNVLEAI 660
EPGVVCAGHD NNQPDSFAAL LSSLNELGER QLVHVVKWAK ALPGFRNLHV DDQMAVIQYS 720
WMGLMVFAMG WRSFTNVNSR MLYFAPDLVF NEYRMHKSRM YSQCVRMRHL SQEFGWLQIT 780
PQEFLCMKAL LLFSIIPVDG LKNQKFFDEL RMNYIKELDR IIACKRKNPT SCSRRFYQLT 840
KLLDSVQPIA RELHQFTFDL LIKSHMVSVD FPEMMAEIIS VQVPKILSGK VKPIYFHTQ 899 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0000790; C:nuclear chromatin; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0043234; C:protein complex; ISO:MGI.
 GO:0005497; F:androgen binding; IEA:Compara.
 GO:0004882; F:androgen receptor activity; ISS:UniProtKB.
 GO:0008013; F:beta-catenin binding; ISS:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0070974; F:POU domain binding; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060520; P:activation of prostate induction by androgen receptor signaling pathway; IMP:MGI.
 GO:0060742; P:epithelial cell differentiation involved in prostate gland development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0060599; P:lateral sprouting involved in mammary gland duct morphogenesis; IMP:MGI.
 GO:0048808; P:male genitalia morphogenesis; IMP:MGI.
 GO:0008584; P:male gonad development; IMP:MGI.
 GO:0019102; P:male somatic sex determination; IMP:MGI.
 GO:0060749; P:mammary gland alveolus development; IMP:MGI.
 GO:0060571; P:morphogenesis of an epithelial fold; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
 GO:0045720; P:negative regulation of integrin biosynthetic process; ISS:UniProtKB.
 GO:0048645; P:organ formation; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IMP:MGI.
 GO:0045726; P:positive regulation of integrin biosynthetic process; IEA:Compara.
 GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IMP:MGI.
 GO:0043410; P:positive regulation of MAPK cascade; IMP:MGI.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
 GO:0042327; P:positive regulation of phosphorylation; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; IEA:Compara.
 GO:0060740; P:prostate gland epithelium morphogenesis; IMP:MGI.
 GO:0060736; P:prostate gland growth; IMP:MGI.
 GO:0051259; P:protein oligomerization; ISO:MGI.
 GO:0050790; P:regulation of catalytic activity; IMP:MGI.
 GO:0048638; P:regulation of developmental growth; IMP:MGI.
 GO:0090003; P:regulation of establishment of protein localization to plasma membrane; ISS:UniProtKB.
 GO:0060685; P:regulation of prostatic bud formation; IGI:MGI.
 GO:0003073; P:regulation of systemic arterial blood pressure; IGI:MGI.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0007283; P:spermatogenesis; IMP:MGI.
 GO:0060748; P:tertiary branching involved in mammary gland duct morphogenesis; IMP:MGI. 
Interpro
 IPR001103; Andrgn_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF02166; Androgen_recep
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00521; ANDROGENR.
 PR00047; STROIDFINGER.