UniProt Accession

 CD3Z_HUMAN; P20963; B1AK49; Q5VX13; Q8TAX4 

Genbank Protein ID

 J04132; AK313946; DQ072717; AL359962; AL031733; AL359962; AL031733; AL031733; AL359962; AL031733; AL359962; CH471067; BC025703 

Genbank Nucleotide ID

 AAA60394.1; BAG36664.1; AAY57330.1; CAH69974.1; CAH69974.1; CAH69975.1; CAH69975.1; CAI21380.1; CAI21380.1; CAI21381.1; CAI21381.1; EAW90792.1; AAH25703.1 

Protein Name

 T-cell surface glycoprotein CD3 zeta chain 

Protein Synonyms/Alias

 T-cell receptor T3 zeta chain; CD247 

Gene Name

 CD247 

Gene Synonyms/Alias

 CD3Z; T3Z; TCRZ 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
99	RDPEMGGKPRRKNPQ	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. 

Sequence Annotation

 DOMAIN 61 89 ITAM 1.
 DOMAIN 100 128 ITAM 2.
 DOMAIN 131 159 ITAM 3.
 MOD_RES 58 58 Phosphoserine.
 MOD_RES 64 64 Phosphotyrosine.
 MOD_RES 72 72 Phosphotyrosine.
 MOD_RES 83 83 Phosphotyrosine.
 MOD_RES 111 111 Phosphotyrosine.
 MOD_RES 123 123 Phosphotyrosine.
 MOD_RES 142 142 Phosphotyrosine.
 MOD_RES 153 153 Phosphotyrosine.
 DISULFID 32 32 Interchain (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Host-virus interaction; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 164 AA 

Protein Sequence

Gene Ontology

 GO:0042105; C:alpha-beta T cell receptor complex; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042101; C:T cell receptor complex; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; NAS:UniProtKB.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
 GO:0031295; P:T cell costimulation; TAS:Reactome.
 GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.
 GO:0016032; P:viral reproduction; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR021663; CR3_zeta/IgE_Fc_rcpt_gamma.
 IPR003110; Phos_immunorcpt_sig_ITAM.
 IPR024128; T-cell_CD3_zeta/eta. 

Pfam

 PF02189; ITAM
 PF11628; TCR_zetazeta 

SMART

 SM00077; ITAM 

PROSITE

 PS51055; ITAM_1 

PRINTS