| Tag | Content |
|---|
| CPLM ID | CPLM-010956 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Desmocollin-2 |
Protein Synonyms/Alias | Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III |
Gene Name | DSC2 |
Gene Synonyms/Alias | CDHF2; DSC3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 890 | FLDNLEPKFRTLAEA | ubiquitination | [1, 2] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
Sequence Annotation | DOMAIN 136 243 Cadherin 1.
DOMAIN 244 355 Cadherin 2.
DOMAIN 356 471 Cadherin 3.
DOMAIN 472 579 Cadherin 4.
DOMAIN 580 694 Cadherin 5.
MOD_RES 864 864 Phosphoserine (Potential).
CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).
CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
CARBOHYD 392 392 N-linked (GlcNAc...).
CARBOHYD 546 546 N-linked (GlcNAc...).
CARBOHYD 629 629 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Calcium; Cardiomyopathy; Cell adhesion; Cell junction; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Disease mutation; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 901 AA |
Protein Sequence | MEAARPSGSW NGALCRLLLL TLAILIFASD ACKNVTLHVP SKLDAEKLVG RVNLKECFTA 60
ANLIHSSDPD FQILEDGSVY TTNTILLSSE KRSFTILLSN TENQEKKKIF VFLEHQTKVL 120
KKRHTKEKVL RRAKRRWAPI PCSMLENSLG PFPLFLQQVQ SDTAQNYTIY YSIRGPGVDQ 180
EPRNLFYVER DTGNLYCTRP VDREQYESFE IIAFATTPDG YTPELPLPLI IKIEDENDNY 240
PIFTEETYTF TIFENCRVGT TVGQVCATDK DEPDTMHTRL KYSIIGQVPP SPTLFSMHPT 300
TGVITTTSSQ LDRELIDKYQ LKIKVQDMDG QYFGLQTTST CIINIDDVND HLPTFTRTSY 360
VTSVEENTVD VEILRVTVED KDLVNTANWR ANYTILKGNE NGNFKIVTDA KTNEGVLCVV 420
KPLNYEEKQQ MILQIGVVNE APFSREASPR SAMSTATVTV NVEDQDEGPE CNPPIQTVRM 480
KENAEVGTTS NGYKAYDPET RSSSGIRYKK LTDPTGWVTI DENTGSIKVF RSLDREAETI 540
KNGIYNITVL ASDQGGRTCT GTLGIILQDV NDNSPFIPKK TVIICKPTMS SAEIVAVDPD 600
EPIHGPPFDF SLESSTSEVQ RMWRLKAIND TAARLSYQND PPFGSYVVPI TVRDRLGMSS 660
VTSLDVTLCD CITENDCTHR VDPRIGGGGV QLGKWAILAI LLGIALLFCI LFTLVCGASG 720
TSKQPKVIPD DLAQQNLIVS NTEAPGDDKV YSANGFTTQT VGASAQGVCG TVGSGIKNGG 780
QETIEMVKGG HQTSESCRGA GHHHTLDSCR GGHTEVDNCR YTYSEWHSFT QPRLGEKVYL 840
CNQDENHKHA QDYVLTYNYE GRGSVAGSVG CCSERQEEDG LEFLDNLEPK FRTLAEACMK 900
R 901 |
Gene Ontology | GO:0005913; C:cell-cell adherens junction; IEA:Compara. GO:0030057; C:desmosome; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IMP:BHF-UCL. GO:0007155; P:cell adhesion; TAS:ProtInc. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL. GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IMP:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |