| Tag | Content |
|---|
| CPLM ID | CPLM-013832 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NAD-dependent protein deacetylase sirtuin-2 |
Protein Synonyms/Alias | Regulatory protein SIR2 homolog 2; SIR2-like protein 2 |
Gene Name | SIRT2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
NCBI Taxa ID | 9601 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 250 | TPRLLINKEKAGQSD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA (By similarity). |
Sequence Annotation | DOMAIN 28 303 Deacetylase sirtuin-type.
NP_BIND 47 67 NAD (By similarity).
NP_BIND 130 133 NAD (By similarity).
NP_BIND 224 226 NAD (By similarity).
NP_BIND 249 251 NAD (By similarity).
ACT_SITE 150 150 Proton acceptor (By similarity).
METAL 158 158 Zinc (By similarity).
METAL 163 163 Zinc (By similarity).
METAL 184 184 Zinc (By similarity).
METAL 187 187 Zinc (By similarity).
BINDING 287 287 NAD; via amide nitrogen (By similarity). |
Keyword | Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Hydrolase; Metal-binding; Microtubule; Mitosis; NAD; Phosphoprotein; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 352 AA |
Protein Sequence | MDFLRNLFSQ TLSLGSQKER LLDELTLEGV ARYMQSERCR RVICLVGAGI STSAGIPDFR 60
SPSTGLYDNL EKYHLPYPEA IFEISYFKKH PEPFFALAKE LYPGQFKPTI CHYFMRLLKD 120
KGLLLRCYTQ NIDTLERIAG LEQEDLVEAH GTFYTSHCVS ASCRHEYPLS WMKEKIFSEV 180
TPKCEDCQSL VKPDIVFFGE SLPARFFSCM QSDFLKVDLL LVMGTSLQVQ PFASLISKAP 240
LSTPRLLINK EKAGQSDPFL GMIMGLGGGM DFDSKKAYRD VAWLGECDQG CLALAELLGW 300
KKELEDLVRR EHASIDAQSG AGVPNPSTSA SPKKSPPPAK DEARTTEREK PQ 352 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro. GO:0070403; F:NAD+ binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. GO:0006476; P:protein deacetylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |