UniProt Accession

 A8K327_HUMAN; A8K327 

Genbank Protein ID

 AP001992; BC136397; BC144059; AK290442; AK022450; CH471076 

Genbank Nucleotide ID

 AAI36398.1; AAI44060.1; BAF83131.1; BAG51074.1; EAW74953.1 

Protein Name

 NEU3 protein 

Protein Synonyms/Alias

 Sialidase 3 (Membrane sialidase), isoform CRA_a; Sialidase-3; cDNA FLJ12388 fis, clone MAMMA1002655, highly similar to Sialidase-3 (EC 3.2.1.18); cDNA FLJ78026 

Gene Name

 NEU3 

Gene Synonyms/Alias

 hCG_27401 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
77	TFLAFAEKRSTRRDE	ubiquitination	[1, 2]
107	LVQWGPLKPLMEATL	ubiquitination	[1, 2, 3]
187	EVIGSELKHWATFAV	ubiquitination	[1, 2, 3]
334	RCQDSSSKDAPTIQQ	ubiquitination	[1, 2, 3]
459	GRNPSQFKSN*****	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 461 AA 

Protein Sequence

Gene Ontology

 GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro. 

Interpro

 IPR026944; Sialidase-3.
 IPR026856; Sialidase_fam.
 IPR011040; Sialidases. 

Pfam

  

SMART

  

PROSITE

  

PRINTS