CPLM-004438

Genbank Nucleotide ID

Platelet endothelial cell adhesion molecule

Protein Synonyms/Alias

PECAM-1; EndoCAM; GPIIA'; PECA1; CD31

Homo sapiens (Human)

Position	Peptide	Type	References
158	NCSVPEEKAPIHFTI	ubiquitination	[1]
167	PIHFTIEKLELNEKM	ubiquitination	[1]

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

DOMAIN 35 121 Ig-like C2-type 1.
DOMAIN 145 233 Ig-like C2-type 2.
DOMAIN 236 315 Ig-like C2-type 3.
DOMAIN 328 401 Ig-like C2-type 4.
DOMAIN 424 493 Ig-like C2-type 5.
DOMAIN 499 591 Ig-like C2-type 6.
REGION 721 738 May play a role in cytoprotective
MOD_RES 690 690 Phosphotyrosine; by FER.
MOD_RES 713 713 Phosphotyrosine; by FER.
LIPID 622 622 S-palmitoyl cysteine.
CARBOHYD 52 52 N-linked (GlcNAc...) (Potential).
CARBOHYD 84 84 N-linked (GlcNAc...).
CARBOHYD 151 151 N-linked (GlcNAc...).
CARBOHYD 301 301 N-linked (GlcNAc...) (Potential).
CARBOHYD 320 320 N-linked (GlcNAc...).
CARBOHYD 344 344 N-linked (GlcNAc...) (Potential).
CARBOHYD 356 356 N-linked (GlcNAc...) (Potential).
CARBOHYD 453 453 N-linked (GlcNAc...).
CARBOHYD 551 551 N-linked (GlcNAc...).
DISULFID 57 109 Potential.
DISULFID 152 206 Potential.
DISULFID 256 304 Potential.
DISULFID 347 386 Potential.
DISULFID 431 476 Potential.
DISULFID 523 572 Potential.

3D-structure; Alternative splicing; Cell adhesion; Cell junction; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Phagocytosis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0031092; C:platelet alpha granule membrane; TAS:Reactome.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0008037; P:cell recognition; TAS:ProtInc.
GO:0050904; P:diapedesis; IDA:UniProtKB.
GO:0072011; P:glomerular endothelium development; IEP:UniProtKB.
GO:0006909; P:phagocytosis; IDA:UniProtKB.
GO:0030168; P:platelet activation; TAS:Reactome.
GO:0002576; P:platelet degranulation; TAS:Reactome.
GO:0007165; P:signal transduction; TAS:ProtInc.

IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.