CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038242
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glucocorticoid receptor 
Protein Synonyms/Alias
  
Gene Name
 Nr3c1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
297LPQVKTEKDDFIELCubiquitination[1]
515RKTKKKIKGIQQATAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 793 AA 
Protein Sequence
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA AASQADSKQQ 60
RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV SLSMGLYMGE TETKVMGNDL 120
GYPQQGQLGL SSGETDFRLL EESIANLNRS TSRPENPKSS TPAAGCATPT EKEFPQTHSD 180
PSSEQQNRKS QPGTNGGSVK LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN 240
LLSPLAGEDD PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF 300
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH YDMNTASLSQ 360
QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF AGRSVFSNGY SSPGMRPDVS 420
SPPSSSSTAT GPPPKLCLVC SDEASGCHYG VLTCGSCKVF FKRAVEGRQH NYLCAGRNDC 480
IIDKIRRKNC PACRYRKCLQ AGMNLEARKT KKKIKGIQQA TAGVSQDTSE NANKTIVPAA 540
LPQLTPTLVS LLEVIEPEVL YAGYDSSVPD SAWRIMTTLN MLGGRQVIAA VKWAKAIPGF 600
RNLHLDDQMT LLQYSWMFLM AFALGWRSYR QASGNLLCFA PDLIINEQRM TLPCMYDQCK 660
HMLFISTELQ RLQVSYEEYL CMKTLLLLSS VPKEGLKSQE LFDEIRMTYI KELGKAIVKR 720
EGNSSQNWQR FYQLTKLLDS MHDVVENLLS YCFQTFLDKS MSIEFPEMLA EIITNQIPKY 780
SNGNIKKLLF HQK 793 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004883; F:glucocorticoid receptor activity; IDA:MGI.
 GO:0046983; F:protein dimerization activity; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0005496; F:steroid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030325; P:adrenal gland development; IMP:MGI.
 GO:0008211; P:glucocorticoid metabolic process; IMP:MGI.
 GO:0060603; P:mammary gland duct morphogenesis; IMP:MGI.
 GO:0043525; P:positive regulation of neuron apoptotic process; IGI:MGI.
 GO:0031946; P:regulation of glucocorticoid biosynthetic process; IMP:MGI.
 GO:0006111; P:regulation of gluconeogenesis; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001409; Glcrtcd_rcpt.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF02155; GCR
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00528; GLCORTICOIDR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.