CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021467
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosome production factor 2 homolog 
Protein Synonyms/Alias
 Brix domain-containing protein 1; Ribosome biogenesis protein RPF2 homolog 
Gene Name
 RPF2 
Gene Synonyms/Alias
 BXDC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37IKNAMLIKGGNANATubiquitination[1]
98MFGSHNKKRPNNLVIubiquitination[1]
160TEDYRRLKSLLIDFFubiquitination[1, 2]
241DLYKLSMKMPKALKPubiquitination[1]
270YGRIHMQKQDLSKLQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 DOMAIN 31 234 Brix.  
Keyword
 Complete proteome; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
MDTLDRVVKP KTKRAKRFLE KREPKLNENI KNAMLIKGGN ANATVTKVLK DVYALKKPYG 60
VLYKKKNITR PFEDQTSLEF FSKKSDCSLF MFGSHNKKRP NNLVIGRMYD YHVLDMIELG 120
IENFVSLKDI KNSKCPEGTK PMLIFAGDDF DVTEDYRRLK SLLIDFFRGP TVSNIRLAGL 180
EYVLHFTALN GKIYFRSYKL LLKKSGCRTP RIELEEMGPS LDLVLRRTHL ASDDLYKLSM 240
KMPKALKPKK KKNISHDTFG TTYGRIHMQK QDLSKLQTRK MKGLKKRPAE RITEDHEKKS 300
KRIKKN 306 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:HPA. 
Interpro
 IPR007109; Brix. 
Pfam
 PF04427; Brix 
SMART
 SM00879; Brix 
PROSITE
 PS50833; BRIX 
PRINTS