UniProt Accession

 MOAE_ECOLI; P30749 

Genbank Protein ID

 X70420; U00096; AP009048 

Genbank Nucleotide ID

 CAA49865.1; AAC73872.1; BAA35443.1 

Protein Name

 Molybdopterin synthase catalytic subunit 

Protein Synonyms/Alias

 MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 

Gene Name

 moaE 

Gene Synonyms/Alias

 chlA5; b0785; JW0768 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
61	HYPGMTEKALAEIVD	acetylation	[1]
119	QFIMDYLKTRAPFWK	acetylation	[1]
148	ESDQQAAKRW*****	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD. 

Sequence Annotation

 REGION 37 39 Substrate binding (By similarity).
 REGION 103 104 Substrate binding (By similarity).
 REGION 126 128 Substrate binding (By similarity).
 BINDING 119 119 Substrate (By similarity).
 CROSSLNK 119 119 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Isopeptide bond; Molybdenum cofactor biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR003448; Mopterin_biosynth_MoaE. 

Pfam

 PF02391; MoaE 

SMART

  

PROSITE

  

PRINTS