| Tag | Content |
|---|
| CPLM ID | CPLM-021502 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Caspase activity and apoptosis inhibitor 1 |
Protein Synonyms/Alias | Conserved anti-apoptotic protein; CAAP |
Gene Name | CAAP1 |
Gene Synonyms/Alias | C9orf82; CAAP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 189 | QLELLSEKKILKILE | ubiquitination | [1] | | 190 | LELLSEKKILKILEG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. |
Sequence Annotation | MOD_RES 203 203 Phosphoserine.
MOD_RES 312 312 Phosphoserine. |
Keyword | Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 361 AA |
Protein Sequence | MTGKKSSREK RRKRSSQEAA AALAAPDIVP ALASGSSGST SGCGSAGGCG SVSCCGNANF 60
SGSVTGGGSG GSCWGGSSVE RSERRKRRST DSSSVSGSLQ QETKYILPTL EKELFLAEHS 120
DLEEGGLDLT VSLKPVSFYI SDKKEMLQQC FCIIGEKKLQ KMLPDVLKNC SIEEIKKLCQ 180
EQLELLSEKK ILKILEGDNG MDSDMEEEAD DGSKMGSDLV SQQDICIDSA SSVRENKQPE 240
GLELKQGKGE DSDVLSINAD AYDSDIEGPC NEEAAAPEAP ENTVQSEAGQ IDDLEKDIEK 300
SVNEILGLAE SSPNEPKAAT LAVPPPEDVQ PSAQQLELLE LEMRARAIKA LMKAGDIKKP 360
A 361 |
Gene Ontology | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |