CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000831
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Natural resistance-associated macrophage protein 2 
Protein Synonyms/Alias
 NRAMP 2; Divalent cation transporter 1; Divalent metal transporter 1; DMT-1 
Gene Name
 Slc11a2 
Gene Synonyms/Alias
 Dct1; Dmt1; Nramp2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
561DTSGGNTK*******ubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Important in metal transport, in particular iron. Can also transport zinc, manganese, cobalt, cadmium, copper, nickel and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. 
Sequence Annotation
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 564 564 Phosphoserine (By similarity).
 MOD_RES 567 567 Phosphoserine (By similarity).
 CARBOHYD 336 336 N-linked (GlcNAc...) (Potential).
 CARBOHYD 349 349 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Endosome; Glycoprotein; Ion transport; Iron; Iron transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 568 AA 
Protein Sequence
MVLDPEEKIP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY FDEKIPIPEE 60
EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR 120
LAARLGVVTG LHLAEVCHRQ YPKVPRIILW LMVELAIIGS DMQEVIGSAI AINLLSAGRV 180
PLYGGVLITI ADTFVFLFLD KYGLRKLEAF FGFLITIMAL TFGYEYVTVK PSQSQVLRGM 240
FVPSCSGCHT PQVEQAVGIV GAVIMPHNMY LHSALVKSRQ VNRANKQEVR EANKYFFIES 300
CIALFVSFII NVFVVSVFAE AFFEKTNEQV VEVCRNSSSP HADLFPNDNS TLAVDIYKGG 360
VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG FLNLKWSRFA RVILTRSIAI 420
IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL PFALIPILTF TSLRPVMSEF SNGIGWRIAG 480
GILVLLVCSI NMYFVVVYVQ ELGHVALYVV AAVVSVAYLG FVFYLGWQCL IALGLSFLDC 540
GRSVSISKVL LSEDTSGGNT K 561 
Gene Ontology
 GO:0045177; C:apical part of cell; IDA:RGD.
 GO:0016021; C:integral to membrane; IDA:RGD.
 GO:0031902; C:late endosome membrane; IDA:RGD.
 GO:0005765; C:lysosomal membrane; IDA:RGD.
 GO:0046870; F:cadmium ion binding; IDA:RGD.
 GO:0015086; F:cadmium ion transmembrane transporter activity; IDA:RGD.
 GO:0050897; F:cobalt ion binding; IDA:RGD.
 GO:0015087; F:cobalt ion transmembrane transporter activity; IDA:RGD.
 GO:0005507; F:copper ion binding; IDA:RGD.
 GO:0005375; F:copper ion transmembrane transporter activity; IDA:RGD.
 GO:0015093; F:ferrous iron transmembrane transporter activity; IMP:RGD.
 GO:0005506; F:iron ion binding; IDA:RGD.
 GO:0015094; F:lead ion transmembrane transporter activity; IDA:RGD.
 GO:0030145; F:manganese ion binding; IDA:RGD.
 GO:0005384; F:manganese ion transmembrane transporter activity; IDA:RGD.
 GO:0016151; F:nickel cation binding; IDA:RGD.
 GO:0015099; F:nickel cation transmembrane transporter activity; IDA:RGD.
 GO:0008270; F:zinc ion binding; IDA:RGD.
 GO:0071456; P:cellular response to hypoxia; IEP:RGD.
 GO:0071281; P:cellular response to iron ion; IEP:RGD.
 GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
 GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
 GO:0046686; P:response to cadmium ion; IEP:RGD.
 GO:0010288; P:response to lead ion; IEP:RGD.
 GO:0010042; P:response to manganese ion; IMP:RGD. 
Interpro
 IPR001046; NRAMP-like. 
Pfam
 PF01566; Nramp 
SMART
  
PROSITE
  
PRINTS
 PR00447; NATRESASSCMP.