CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020458
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein tweety homolog 3 
Protein Synonyms/Alias
 hTTY3 
Gene Name
 TTYH3 
Gene Synonyms/Alias
 KIAA1691 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
517SHAGWQFKPMDSARTubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. 
Sequence Annotation
 MOD_RES 504 504 Phosphoserine (By similarity).
 MOD_RES 522 522 Phosphoserine.
 CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
 CARBOHYD 144 144 N-linked (GlcNAc...).
 CARBOHYD 351 351 N-linked (GlcNAc...) (Probable).  
Keyword
 Alternative splicing; Calcium; Cell membrane; Chloride; Chloride channel; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MAGVSYAAPW WVSLLHRLPH FDLSWEATSS QFRPEDTDYQ QALLLLGAAA LACLALDLLF 60
LLFYSFWLCC RRRKSEEHLD ADCCCTAWCV IIATLVCSAG IAVGFYGNGE TSDGIHRATY 120
SLRHANRTVA GVQDRVWDTA VGLNHTAEPS LQTLERQLAG RPEPLRAVQR LQGLLETLLG 180
YTAAIPFWRN TAVSLEVLAE QVDLYDWYRW LGYLGLLLLD VIICLLVLVG LIRSSKGILV 240
GVCLLGVLAL VISWGALGLE LAVSVGSSDF CVDPDAYVTK MVEEYSVLSG DILQYYLACS 300
PRAANPFQQK LSGSHKALVE MQDVVAELLR TVPWEQPATK DPLLRVQEVL NGTEVNLQHL 360
TALVDCRSLH LDYVQALTGF CYDGVEGLIY LALFSFVTAL MFSSIVCSVP HTWQQKRGPD 420
EDGEEEAAPG PRQAHDSLYR VHMPSLYSCG SSYGSETSIP AAAHTVSNAP VTEYMSQNAN 480
FQNPRCENTP LIGRESPPPS RYLAALDSGS HAGWQFKPMD SARTLW 526 
Gene Ontology
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005254; F:chloride channel activity; IMP:UniProtKB. 
Interpro
 IPR006990; Tweety. 
Pfam
 PF04906; Tweety 
SMART
  
PROSITE
  
PRINTS