CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018620
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinoid-inducible serine carboxypeptidase 
Protein Synonyms/Alias
 Serine carboxypeptidase 1 
Gene Name
 Scpep1 
Gene Synonyms/Alias
 Risc 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
243QVLNAVNKGFYKEATacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May be involved in vascular wall and kidney homeostasis. 
Sequence Annotation
 ACT_SITE 167 167 By similarity.
 ACT_SITE 371 371 By similarity.
 ACT_SITE 431 431 By similarity.
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).
 CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
 CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).  
Keyword
 Carboxypeptidase; Complete proteome; Glycoprotein; Hydrolase; Protease; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MELSRRICLV RLWLLLLSFL LGFSAGSALN WREQEGKEVW DYVTVREDAR MFWWLYYATN 60
PCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDTRLKP RNTTWLQWAS LLFVDNPVGT 120
GFSYVNTTDA YAKDLDTVAS DMMVLLKSFF DCHKEFQTVP FYIFSESYGG KMAAGISLEL 180
HKAIQQGTIK CNFSGVALGD SWISPVDSVL SWGPYLYSVS LLDNKGLAEV SDIAEQVLNA 240
VNKGFYKEAT QLWGKAEMII EKNTDGVNFY NILTKSTPDT SMESSLEFFR SPLVRLCQRH 300
VRHLQGDALS QLMNGPIKKK LKIIPDDVSW GAQSSSVFIS MEEDFMKPVI DIVDTLLELG 360
VNVTVYNGQL DLIVDTIGQE SWVQKLKWPQ LSRFNQLKWK ALYTNPKSSE TSAFVKSYEN 420
LAFYWILKAG HMVPADQGDM ALKMMRLVTQ QE 452 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004185; F:serine-type carboxypeptidase activity; TAS:RGD.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0042573; P:retinoic acid metabolic process; IEP:RGD. 
Interpro
 IPR001563; Peptidase_S10.
 IPR018202; Peptidase_S10_AS. 
Pfam
 PF00450; Peptidase_S10 
SMART
  
PROSITE
 PS00560; CARBOXYPEPT_SER_HIS
 PS00131; CARBOXYPEPT_SER_SER 
PRINTS
 PR00724; CRBOXYPTASEC.