| Tag | Content |
|---|
| CPLM ID | CPLM-016012 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium-dependent secretion activator 1 |
Protein Synonyms/Alias | Calcium-dependent activator protein for secretion 1; CAPS-1 |
Gene Name | Cadps |
Gene Synonyms/Alias | Caps; Caps1; Kiaa1121 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 457 | THALPAVKVKLFTES | ubiquitination | [1] | | 459 | ALPAVKVKLFTESTG | ubiquitination | [1] | | 781 | KERFEEIKERLRVLL | ubiquitination | [1] | | 838 | EVKTVIRKCLEQAAL | ubiquitination | [1] | | 1321 | LDSTLNSKTYETIRN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). |
Sequence Annotation | DOMAIN 398 479 C2.
DOMAIN 519 622 PH.
DOMAIN 933 1113 MHD1.
REGION 792 1131 Interaction with DRD2 (By similarity).
REGION 1179 1355 Mediates targeting and association with |
Keyword | Alternative splicing; Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Exocytosis; Lipid-binding; Membrane; Metal-binding; Protein transport; Reference proteome; Synapse; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1355 AA |
Protein Sequence | MLDPSSSEEE SDEILEEERG KDVLGSAASG ARLSPSRTSE GSAGSAGMGG SGAGAGVGAG 60
GGGGSGASSG GGAGGLQPSS RAGGGRPSSP SPSVVSEKEK EELERLQKEE EERKKRLQLY 120
VFVMRCIAYP FNAKQPTDMA RRQQKISKQQ LQTVKDRFQA FLNGETQIVA DEAFMNAVQS 180
YYEVFLKSDR VARMVQSGGC SANDSREVFK KHIEKRVRSL PEIDGLSKET VLSSWMAKFD 240
AIYRGEEDPR KQQARMTASA ASELILSKEQ LYEMFQNILG IKKFEHQLLY NACQLDNPDE 300
QAAQIRRELD GRLQMADQIA RERKFPKFVS KEMENMYIEE LKSSVNLLMA NLESMPVSKG 360
GEFKLQKLKR SHNASIIDMG EESENQLSKS DVLLSFSLEV VIMEVQGLKS LAPNRIVYCT 420
MEVEGGEKLQ TDQAEASKPT WGTQGDFSTT HALPAVKVKL FTESTGVLAL EDKELGRVIL 480
HPTPNSPKQS EWHKMTVSKN CPDQDLKIKL AVRMDKPQNM KHSGYLWTIG KNVWKRWKKR 540
FFVLVQVSQY TFAMCSYREK KAEPQELLQL DGYTVDYTDP QPGLEGGRAF FNAVKEGDTV 600
IFASDDEQDR ILWVQAMYRA TGQSHKPVPP TQVQKLNAKG GNVPQLDAPI SQFYADRAQK 660
HGMDEFISSN PCNFDHASLF EMVQRLTLDH RLNDSYSCLG WFSPGQVFVL DEYCARNGVR 720
GCHRHLCYLR DLLERAENGA MIDPTLLHYS FAFCASHVHG NRPDGIGTVT VEEKERFEEI 780
KERLRVLLEN QITHFRYCFP FGRPEGALKA TLSLLERVLM KDIVTPVPQE EVKTVIRKCL 840
EQAALVNYSR LSEYAKIEGK KREMYEHPVF CLASQVMDLT IQNVGRLITP AKKLEDTIRL 900
AELVIEVLQQ NEEHHAEAFA WWSDLMVEHA ETFLSLFAVD MDAALEVQPP DTWDSFPLFQ 960
LLNDFLRTDY NLCNGKFHKH LQDLFAPLVV RYVDLMESSI AQSIHRGFER ESWEPVKSLT 1020
SNLPNVNLPN VNLPKVPNLP VNIPLGIPQM PTFSAPSWMA AIYDADNGSG TSEDLFWKLD 1080
ALQTFIRDLH WPEEEFGKHL EQRLKLMASD MIESCVKRTR IAFEVKLQKT SRSTDFRVPQ 1140
SICTMFNVMV DAKAQSTKLC SMEMGQEHQY HSKIDELIEE TVKEMITLLV AKFVTILEGV 1200
LAKLSRYDEG TLFSSFLSFT VKAASKYVDV PKPGMDVADA YVTFVRHSQD VLRDKVNEEM 1260
YIERLFDQWY NSSMNIICTW LTDRMDLQLH IYQLKTLIRM VKKTYRDFRL QGVLDSTLNS 1320
KTYETIRNRL TVEEATASVS EGGGLQGISM KDSDEEDEED D 1361 |
Gene Ontology | |
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