UniProt Accession

 A2AC13_MOUSE; A2AC13 

Genbank Protein ID

 AL663030; CH466558 

Genbank Nucleotide ID

 EDL34795.1 

Protein Name

 RAS-related C3 botulinum substrate 3, isoform CRA_a 

Protein Synonyms/Alias

 Ras-related C3 botulinum toxin substrate 3 

Gene Name

 Rac3 

Gene Synonyms/Alias

 mCG_2150 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
89	SFENVRAKWYPEVRH	acetylation	[1]
89	SFENVRAKWYPEVRH	ubiquitination	[2]
159	ALTQRGLKTVFDEAI	acetylation	[1, 3]
159	ALTQRGLKTVFDEAI	succinylation	[3]
159	ALTQRGLKTVFDEAI	ubiquitination	[2]
176	VLCPPPVKKPGKKCT	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; GTP-binding; Membrane; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0031941; C:filamentous actin; ISO:MGI.
 GO:0030426; C:growth cone; ISO:MGI.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; ISO:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0031175; P:neuron projection development; IDA:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.