CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040048
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nodal modulator 3 
Protein Synonyms/Alias
  
Gene Name
 NOMO3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MARFAFFKVLPGDYEubiquitination[1]
26THPTWALKEASTTVRubiquitination[1, 2, 3]
64RSDGEPMKGVKFLLFubiquitination[1]
152TVEHDSLKIEPVFHVubiquitination[4]
189VTLNNQIKVKTKADGubiquitination[1, 2, 3]
257IRFPDTVKQMNKYKVubiquitination[1]
263VKQMNKYKVVLSSQDubiquitination[1]
271VVLSSQDKDKSLVTVubiquitination[1]
273LSSQDKDKSLVTVETubiquitination[1]
296KANPGTYKVQVMVPEubiquitination[1]
387FDNVLPGKYKISIMHubiquitination[1, 2, 3, 5]
463VNRFCLSKPGVYKVTubiquitination[1, 5, 6]
468LSKPGVYKVTPRSCHubiquitination[1]
533ALVLGPLKSVQELRRubiquitination[1, 2, 3]
595YWARSGEKITVTPSSubiquitination[1, 2]
603ITVTPSSKELLFYPPubiquitination[1, 3, 4]
760SPGQYYFKPMMKEFRubiquitination[1, 4]
764YYFKPMMKEFRFEPSubiquitination[4]
852CVYHVQLKAEGNDHIubiquitination[1]
912TLWVKLYKSENLDNPubiquitination[3]
1044NSGPEDAKRQAKKQKubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1100 AA 
Protein Sequence
MARFAFFKVL PGDYEILATH PTWALKEAST TVRVTNSNAN AASPLIVAGY NVSGSVRSDG 60
EPMKGVKFLL FSSLVTKEDV LGCNVSPVPG FQPQDESLVY LCYTVSREDG SFSFYSLPSG 120
GYTVIPFYRG ERITFDVAPS RLDFTVEHDS LKIEPVFHVM GFSVTGRVLN GPEGDGVPEA 180
VVTLNNQIKV KTKADGSFRL ENITTGTYTI HAQKEHLYFE TVTIKIAPNT PQLADIVATG 240
FSVCGQISII RFPDTVKQMN KYKVVLSSQD KDKSLVTVET DAHGSFCFKA NPGTYKVQVM 300
VPEAETRAGL TLKPQTFPLT VTDRPVMDVA FVQFLASVSG KVSCLDTCGD LLVTLQSLSR 360
QGEKRSLQLS GKVNAMTFTF DNVLPGKYKI SIMHEDWCWK NKSLEVEVLE DDVSAVEFRQ 420
TGYMLRCSLS HAITLEFYQD GNGRENVGIY NLSKGVNRFC LSKPGVYKVT PRSCHRFEQA 480
FYTYDTSSPS ILTLTAIRHH VLGTITTDKM MDVTVTIKSS IDSEPALVLG PLKSVQELRR 540
EQQLAEIEAR RQEREKNGNE EGEERMTKPP VQEMVDELQG PFSYDFSYWA RSGEKITVTP 600
SSKELLFYPP SMEAVVSGES CPGKLIEIHG KAGLFLEGQI HPELEGVEIV ISEKGASSPL 660
ITVFTDDKGA YSVGPLHSDL EYTVTSQKEG YVLTAVEGTI GDFKAYALAG VSFEIKAEDD 720
QPLPGVLLSL SGGLFRSNLL TQDNGILTFS NLSPGQYYFK PMMKEFRFEP SSQMIEVQEG 780
QNLKITITGY RTAYSCYGTV SSLNGEPEQG VAMEAVGQND CSIYGEDTVT DEEGKFRLRG 840
LLPGCVYHVQ LKAEGNDHIE RALPHHRVIE VGNNDIDDVN IIVFRQINQF DLSGNVITSS 900
EYLPTLWVKL YKSENLDNPI QTVSLGQSLF FHFPPLLRDG ENYVVLLDST LPRSQYDYIL 960
PQVSFTAVGY HKHITLIFNP TRKLPEQDIA QGSYIALPLT LLVLLAGYNH DKLIPLLLQL 1020
TSRLQGVGAL GQAASDNSGP EDAKRQAKKQ KTRRTLRLQE EFQLMWCLVP WRGTLGIHLF 1080
SSLPFASEIL LETTATCIHY 1100 
Gene Ontology
 GO:0030246; F:carbohydrate binding; IEA:InterPro. 
Interpro
 IPR013784; Carb-bd-like_fold.
 IPR008969; CarboxyPept-like_regulatory.
 IPR014766; CarboxyPept_regulatory_dom.
 IPR013783; Ig-like_fold.
 IPR027064; NOMO. 
Pfam
  
SMART
  
PROSITE
  
PRINTS