UniProt Accession

 PTRF_MOUSE; O54724; Q2TAW6 

Genbank Protein ID

 AF036249; AF458959; AL591466; BC110698; BC117527; BC116701 

Genbank Nucleotide ID

 AAC53588.1; AAL60240.1; CAM19459.1; AAI10699.1; AAI17528.1; AAI16702.1 

Protein Name

 Polymerase I and transcript release factor 

Protein Synonyms/Alias

 Cav-p60; Cavin-1 

Gene Name

 Ptrf 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
47	TGSDELIKSDQVNGV	ubiquitination	[1]
97	SIQGELSKLGKAHAT	ubiquitination	[1]
100	GELSKLGKAHATTSN	ubiquitination	[1]
111	TTSNTVSKLLEKVRK	acetylation	[2]
111	TTSNTVSKLLEKVRK	ubiquitination	[1]
115	TVSKLLEKVRKVSVN	ubiquitination	[1]
124	RKVSVNVKTVRGSLE	ubiquitination	[1]
139	RQAGQIKKLEVNEAE	ubiquitination	[1]
154	LLRRRNFKVMIYQDE	acetylation	[3]
154	LLRRRNFKVMIYQDE	ubiquitination	[1]
163	MIYQDEVKLPAKLSV	ubiquitination	[1]
167	DEVKLPAKLSVSKSL	ubiquitination	[1]
172	PAKLSVSKSLKESEA	ubiquitination	[1]
175	LSVSKSLKESEALPE	ubiquitination	[1]
301	TSRDKLRKSFTPDHV	ubiquitination	[1]
319	RSKTAVYKVPPFTFH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 38 38 Phosphoserine.
 MOD_RES 40 40 Phosphothreonine.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 169 169 Phosphoserine.
 MOD_RES 177 177 Phosphoserine.
 MOD_RES 204 204 Phosphoserine (By similarity).
 MOD_RES 205 205 Phosphoserine (By similarity).
 MOD_RES 302 302 Phosphoserine.
 MOD_RES 304 304 Phosphothreonine (By similarity).
 MOD_RES 367 367 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.
 MOD_RES 389 389 Phosphoserine (By similarity).
 MOD_RES 391 391 Phosphoserine (By similarity).  

Keyword

 Acetylation; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane; Microsome; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; rRNA-binding; Transcription; Transcription regulation; Transcription termination. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0042134; F:rRNA primary transcript binding; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006363; P:termination of RNA polymerase I transcription; IDA:UniProtKB.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; IDA:UniProtKB. 

Interpro

 IPR026752; Cavin_fam. 

Pfam

  

SMART

  

PROSITE

  

PRINTS