UniProt Accession

 LAP2_RAT; Q62733 

Genbank Protein ID

 U18314 

Genbank Nucleotide ID

 AAC52209.1 

Protein Name

 Lamina-associated polypeptide 2, isoform beta 

Protein Synonyms/Alias

 Thymopoietin isoform beta; TP beta 

Gene Name

 Tmpo 

Gene Synonyms/Alias

 Lap2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
13	EDPSVLTKDKLKSEL	acetylation	[1]
206	EPLKGRAKTPVTLKQ	acetylation	[1]
333	TRAEVGEKTEERRVE	acetylation	[1]
388	MEESFSSKYVPKYVP	acetylation	[1]
392	FSSKYVPKYVPLADV	acetylation	[1]
400	YVPLADVKSEKTKKG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds directly to lamin B1 and chromosomes in a mitotic phosphorylation-regulated manner. May play an important role in nuclear envelope reassembly at the end of mitosis and/or anchoring of the nuclear lamina and interphase chromosomes to the nuclear envelope. 

Sequence Annotation

 DOMAIN 5 48 LEM-like.
 DOMAIN 108 152 LEM.
 REGION 1 409 Nucleoplasmic (Potential).
 REGION 49 107 Linker.
 REGION 137 242 NAKAP95-binding N.
 REGION 298 370 Binds lamins B.
 REGION 299 373 NAKAP95-binding C.
 MOD_RES 66 66 Phosphoserine (By similarity).
 MOD_RES 67 67 Phosphoserine (By similarity).
 MOD_RES 74 74 Phosphothreonine (By similarity).
 MOD_RES 155 155 Phosphoserine (By similarity).
 MOD_RES 159 159 Phosphothreonine (By similarity).
 MOD_RES 176 176 Phosphoserine (By similarity).
 MOD_RES 179 179 Phosphoserine (By similarity).
 MOD_RES 183 183 Phosphoserine (By similarity).
 MOD_RES 207 207 Phosphothreonine (By similarity).  

Keyword

 Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Membrane; Nucleus; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 452 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005637; C:nuclear inner membrane; IDA:RGD.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0005521; F:lamin binding; TAS:RGD.
 GO:0031468; P:nuclear envelope reassembly; NAS:RGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:Compara. 

Interpro

 IPR013146; LEM-like_dom.
 IPR011015; LEM/LEM-like_dom.
 IPR003887; LEM_dom. 

Pfam

 PF03020; LEM
 PF08198; Thymopoietin 

SMART

 SM00540; LEM 

PROSITE

 PS50954; LEM
 PS50955; LEM_LIKE 

PRINTS