CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013804
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Deoxynucleotidyltransferase terminal-interacting protein 2 
Protein Synonyms/Alias
 Estrogen receptor-binding protein; LPTS-interacting protein 2; LPTS-RP2; Terminal deoxynucleotidyltransferase-interacting factor 2; TdIF2; TdT-interacting factor 2 
Gene Name
 DNTTIP2 
Gene Synonyms/Alias
 ERBP; TDIF2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54AESQTTGKQSLIPRTubiquitination[1, 2]
132KPKVTPTKESYTEEIubiquitination[1, 2]
159RIVLPTEKTTGARRSubiquitination[1, 2, 3]
227KIVPGNEKQIVGTPVubiquitination[1]
257RSLSEINKPNFYNNDubiquitination[1]
311NGITDEGKEINEKSSubiquitination[1]
316EGKEINEKSSQLKNLubiquitination[1]
321NEKSSQLKNLSELQDubiquitination[1, 2]
558STKAKLLKLTSSSIDubiquitination[2, 4]
596KRTLTQIKEKKKNELubiquitination[2]
658PEMTNELKNDLKALKubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. 
Sequence Annotation
 REGION 548 605 TdBR region; mediates interaction with
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 117 117 Phosphoserine.
 MOD_RES 129 129 Phosphothreonine.
 MOD_RES 141 141 Phosphoserine.
 MOD_RES 145 145 Phosphoserine.
 MOD_RES 148 148 Phosphoserine.
 MOD_RES 184 184 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 232 232 Phosphothreonine.
 MOD_RES 251 251 Phosphoserine.
 MOD_RES 324 324 Phosphoserine.
 MOD_RES 330 330 Phosphoserine.
 MOD_RES 381 381 Phosphoserine.
 MOD_RES 434 434 Phosphoserine.
 MOD_RES 512 512 Phosphoserine.
 MOD_RES 543 543 Phosphoserine (By similarity).
 MOD_RES 610 610 Phosphothreonine.  
Keyword
 Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 756 AA 
Protein Sequence
MVVTRSARAK ASIQAASAES SGQKSFAANG IQAHPESSTG SDARTTAESQ TTGKQSLIPR 60
TPKARKRKSR TTGSLPKGTE PSTDGETSEA ESNYSVSEHH DTILRVTRRR QILIACSPVS 120
SVRKKPKVTP TKESYTEEIV SEAESHVSGI SRIVLPTEKT TGARRSKAKS LTDPSQESHT 180
EAISDAETSS SDISFSGIAT RRTRSMQRKL KAQTEKKDSK IVPGNEKQIV GTPVNSEDSD 240
TRQTSHLQAR SLSEINKPNF YNNDFDDDFS HRSSENILTV HEQANVESLK ETKQNCKDLD 300
EDANGITDEG KEINEKSSQL KNLSELQDTS LQQLVSQRHS TPQNKNAVSV HSNLNSEAVM 360
KSLTQTFATV EVGRWNNNKK SPIKASDLTK FGDCGGSDDE EESTVISVSE DMNSEGNVDF 420
ECDTKLYTSA PNTSQGKDNS VLLVLSSDES QQSENSENEE DTLCFVENSG QRESLSGDTG 480
SLSCDNALFV IDTTPGMSAD KNFYLEEEDK ASEVAIEEEK EEEEDEKSEE DSSDHDENED 540
EFSDEEDFLN STKAKLLKLT SSSIDPGLSI KQLGGLYINF NADKLQSNKR TLTQIKEKKK 600
NELLQKAVIT PDFEKNHCVP PYSESKYQLQ KKRRKERQKT AGDGWFGMKA PEMTNELKND 660
LKALKMRASM DPKRFYKKND RDGFPKYFQI GTIVDNPADF YHSRIPKKQR KRTIVEELLA 720
DSEFRRYNRR KYSEIMAEKA ANAAGKKFRK KKKFRN 756 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR014810; Fcf2. 
Pfam
 PF08698; Fcf2 
SMART
  
PROSITE
  
PRINTS