CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016748
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Apolipoprotein A-V 
Protein Synonyms/Alias
 Apo-AV; ApoA-V; Apolipoprotein A5; Regeneration-associated protein 3 
Gene Name
 Apoa5 
Gene Synonyms/Alias
 Rap3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
43GVMGQPQKLAQENLKubiquitination[1]
89QDPEGIRKQLQQELGubiquitination[1]
183LHHTDRVKELFHPYAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). 
Sequence Annotation
  
Keyword
 Chylomicron; Coiled coil; Complete proteome; HDL; Lipid transport; Phosphoprotein; Reference proteome; Secreted; Signal; Transport; VLDL. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 368 AA 
Protein Sequence
MAAVITWALA LLAVFASTQA RKSLWDYFSQ NSWSKGVMGQ PQKLAQENLK GSFEQDLYNM 60
NNYLEKLGPL RGPGKEPPLL AQDPEGIRKQ LQQELGEVSS RLEPYMAAKH QQVGWNLEGL 120
RQQLKPYTAE LMEQVGLSVQ ELQEQLRVVG EDTKAQLLGG VDEALNLLQD MQSRVLHHTD 180
RVKELFHPYA ERLVTGIGHH VQELHRSVAP HAAASPARLS RCVQTLSHKL TRKAKDLHTS 240
IQRNLDQLRD ELSAFIRVST DGAEDGDSLD PQALSEEVRQ RLQAFRHDTY LQIAAFTQAI 300
DQETEEIQHQ LAPPPPSHSA FAPELGHSDS NKALSRLQSR LDDLWEDIAY GLQDQGHSHL 360
SDPEGHSG 368 
Gene Ontology
 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0008201; F:heparin binding; IEA:Compara.
 GO:0060230; F:lipoprotein lipase activator activity; IEA:Compara.
 GO:0031210; F:phosphatidylcholine binding; IEA:Compara.
 GO:0055090; P:acylglycerol homeostasis; IMP:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
 GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Compara.
 GO:0010902; P:positive regulation of very-low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0042246; P:tissue regeneration; IEA:Compara.
 GO:0019433; P:triglyceride catabolic process; IEA:Compara.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI.
 GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IMP:MGI. 
Interpro
 IPR013326; ApoA.
 IPR000074; ApoA1_A4_E. 
Pfam
 PF01442; Apolipoprotein 
SMART
  
PROSITE
  
PRINTS