| Tag | Content |
|---|
| CPLM ID | CPLM-007925 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CAAX prenyl protease 1 |
Protein Synonyms/Alias | A-factor-converting enzyme; Prenyl protein-specific endoprotease 1; PPSEP 1 |
Gene Name | STE24 |
Gene Synonyms/Alias | AFC1; YJR117W; J2032 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 398 | YQADAYAKKLGYKQN | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Proteolytically removes the C-terminal three residues of farnesylated A-factor mating pheromone. Also acts to cleave the N- terminal extension of the pheromone. Does not act on Ras. |
Sequence Annotation | ACT_SITE 298 298 By similarity.
ACT_SITE 394 394 Proton donor (By similarity).
METAL 297 297 Zinc; catalytic (By similarity).
METAL 301 301 Zinc; catalytic (By similarity).
METAL 390 390 Zinc; catalytic (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Metal-binding; Metalloprotease; Pheromone response; Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 453 AA |
Protein Sequence | MFDLKTILDH PNIPWKLIIS GFSIAQFSFE SYLTYRQYQK LSETKLPPVL EDEIDDETFH 60
KSRNYSRAKA KFSIFGDVYN LAQKLVFIKY DLFPKIWHMA VSLLNAVLPV RFHMVSTVAQ 120
SLCFLGLLSS LSTLVDLPLS YYSHFVLEEK FGFNKLTVQL WITDMIKSLT LAYAIGGPIL 180
YLFLKIFDKF PTDFLWYIMV FLFVVQILAM TIIPVFIMPM FNKFTPLEDG ELKKSIESLA 240
DRVGFPLDKI FVIDGSKRSS HSNAYFTGLP FTSKRIVLFD TLVNSNSTDE ITAVLAHEIG 300
HWQKNHIVNM VIFSQLHTFL IFSLFTSIYR NTSFYNTFGF FLEKSTGSFV DPVITKEFPI 360
IIGFMLFNDL LTPLECAMQF VMSLISRTHE YQADAYAKKL GYKQNLCRAL IDLQIKNLST 420
MNVDPLYSSY HYSHPTLAER LTALDYVSEK KKN 453 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:SGD. GO:0005741; C:mitochondrial outer membrane; IDA:SGD. GO:0005637; C:nuclear inner membrane; IMP:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004222; F:metalloendopeptidase activity; IDA:SGD. GO:0071586; P:CAAX-box protein processing; IMP:SGD. GO:0007323; P:peptide pheromone maturation; IDA:SGD. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
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