CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045061
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 UBX domain-containing protein 6 
Protein Synonyms/Alias
  
Gene Name
 UBXN6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
96MKIYTFNKDQDRVKLubiquitination[1, 2]
102NKDQDRVKLGVDTIAubiquitination[2, 3, 4, 5]
110LGVDTIAKYLDNIHLubiquitination[2, 3, 4, 5]
123HLHPEEEKYRKIKLQubiquitination[2]
126PEEEKYRKIKLQNKVubiquitination[2]
128EEKYRKIKLQNKVFQubiquitination[2]
132RKIKLQNKVFQERINubiquitination[2, 3]
187PQSLERHKEQLLAAEubiquitination[1, 2]
231NLTAEEIKREQRLRSubiquitination[2, 3, 5]
263EEQRGLRKYNYTLLRubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
XEKAHKEKPN QPAPRPPRQG PTNEAQMAAA AALARLEQKQ SRAWGPTSQD TIRNQVRKEL 60
QAEATVSGSP EAPGTNVHFS TDPVAASIMK IYTFNKDQDR VKLGVDTIAK YLDNIHLHPE 120
EEKYRKIKLQ NKVFQERINC LEGTHEFFEA IGFQKVLLPA QDQEDPEEFY VLSETTLAQP 180
QSLERHKEQL LAAEPVRAKL DRQRRVFQPS PLASQFELPG DFFNLTAEEI KREQRLRSEA 240
VERLSVLRTK AMREKEEQRG LRKYNYTLLR VRLPDGCLLQ GTFYARERLG AVYGFVREAL 300
QSDWLPFELL ASGGQKLSED ENLALNECGL VPSALLTFSW DMAVLEDIKA AGAEPDSILK 360
PELLSAIEKL L 371 
Gene Ontology
  
Interpro
 IPR018997; PUB_domain.
 IPR006567; PUG-dom.
 IPR001012; UBX. 
Pfam
 PF09409; PUB
 PF00789; UBX 
SMART
 SM00580; PUG
 SM00166; UBX 
PROSITE
 PS50033; UBX 
PRINTS