UniProt Accession

 NR1D1_MOUSE; Q3UV55; Q3UJJ1; Q62171; Q6EEZ6; Q922A5; Q9ESY4 

Genbank Protein ID

 AK137398; AK137582; AK146430; AK154931; AK155597; AL590963; BC008989; AF291821; X86010; AY336125 

Genbank Nucleotide ID

 BAE23342.1; BAE23418.1; BAE27164.1; BAE32932.1; BAE33339.1; CAM46187.1; AAH08989.1; AAG01345.1; CAA59997.1; AAS48348.1 

Protein Name

 Nuclear receptor subfamily 1 group D member 1 

Protein Synonyms/Alias

 Rev-erbA-alpha; V-erbA-related protein 1; EAR-1 

Gene Name

 Nr1d1 

Gene Synonyms/Alias

 Ear1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
413	SLRQGNTKNVLLACP	ubiquitination	[1]
456	REVVEFAKHIPGFRD	ubiquitination	[1]
588	SETSRFTKLLLKLPD	ubiquitination	[1]
592	RFTKLLLKLPDLRTL	ubiquitination	[1]
606	LNNMHSEKLLSFRVD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine (By similarity). In collaboration with SP1, activates GJA1 transcription. 

Sequence Annotation

 DNA_BIND 130 206 Nuclear receptor.
 ZN_FING 133 153 NR C4-type.
 ZN_FING 170 194 NR C4-type.  

Keyword

 Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 615 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0007623; P:circadian rhythm; IDA:MGI.
 GO:0010871; P:negative regulation of receptor biosynthetic process; IEA:Compara.
 GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00104; Hormone_recep
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.