UniProt Accession

 RSSB_ECOLI; P0AEV1; P37055 

Genbank Protein ID

 X66003; M64675; U00096; AP009048 

Genbank Nucleotide ID

 CAA46802.1; AAC74317.1; BAA36103.1 

Protein Name

 Regulator of RpoS 

Protein Synonyms/Alias

  

Gene Name

 rssB 

Gene Synonyms/Alias

 hnr; sprE; ychL; b1235; JW1223 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
68	MPRMNGLKLLEHIRN	acetylation	[1]
96	ENMADIAKALRLGVE	acetylation	[1]
246	PELGALLKQVNHLLR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. In stationary phase, could also act as an anti-sigma factor and reduce the ability of RpoS to activate gene expression. Is also involved in the regulation of the mRNA polyadenylation pathway during stationary phase, probably by maintaining the association of PcnB with the degradosome. 

Sequence Annotation

 DOMAIN 9 123 Response regulatory.
 MOD_RES 58 58 4-aspartylphosphate.  

Keyword

 3D-structure; Complete proteome; Phosphoprotein; Reference proteome; Stress response; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0006508; P:proteolysis; EXP:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001789; Sig_transdc_resp-reg_receiver. 

Pfam

 PF00072; Response_reg 

SMART

 SM00448; REC 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS