CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019123
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pleckstrin homology domain-containing family B member 2 
Protein Synonyms/Alias
 PH domain-containing family B member 2; Evectin-2 
Gene Name
 PLEKHB2 
Gene Synonyms/Alias
 EVT2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71DTQPPDGKSKDCMLQubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in retrograde transport of recycling endosomes. 
Sequence Annotation
 DOMAIN 2 109 PH.
 BINDING 20 20 Phosphatidylserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Endosome; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 222 AA 
Protein Sequence
MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP MDCINIRTGQ 60
ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW KFTLQDSRTN TAYVGSAVMT 120
DETSVVSSPP PYTAYAAPAP EQAYGYGPYG GAYPPGTQVV YAANGQAYAV PYQYPYAGLY 180
GQQPANQVII RERYRDNDSD LALGMLAGAA TGMALGSLFW VF 222 
Gene Ontology
 GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS