CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002515
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homoserine O-succinyltransferase 
Protein Synonyms/Alias
 Homoserine O-transsuccinylase; HTS 
Gene Name
 metA 
Gene Synonyms/Alias
 b4013; JW3973 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
37GQEIRPLKVLILNLMacetylation[1]
46LILNLMPKKIETENQacetylation[1]
47ILNLMPKKIETENQFacetylation[1]
163PKQTRTEKLSGVYEHacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 ACT_SITE 142 142 Potential.  
Keyword
 Acyltransferase; Allosteric enzyme; Amino-acid biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; Methionine biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 309 AA 
Protein Sequence
MPIRVPDELP AVNFLREENV FVMTTSRASG QEIRPLKVLI LNLMPKKIET ENQFLRLLSN 60
SPLQVDIQLL RIDSRESRNT PAEHLNNFYC NFEDIQDQNF DGLIVTGAPL GLVEFNDVAY 120
WPQIKQVLEW SKDHVTSTLF VCWAVQAALN ILYGIPKQTR TEKLSGVYEH HILHPHALLT 180
RGFDDSFLAP HSRYADFPAA LIRDYTDLEI LAETEEGDAY LFASKDKRIA FVTGHPEYDA 240
QTLAQEFFRD VEAGLDPDVP YNYFPHNDPQ NTPRASWRSH GNLLFTNWLN YYVYQITPYD 300
LRHMNPTLD 309 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008899; F:homoserine O-succinyltransferase activity; IDA:EcoCyc.
 GO:0019281; P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine; IEA:HAMAP. 
Interpro
 IPR005697; Homserine_suc_trans. 
Pfam
 PF04204; HTS 
SMART
  
PROSITE
  
PRINTS