UniProt Accession

 ITM2C_MOUSE; Q91VK4; Q9JI06; Q9JME8 

Genbank Protein ID

 AB030199; AF272044; AF282981; AK036377; BC012952 

Genbank Nucleotide ID

 BAA92762.1; AAF89493.1; AAK00277.1; BAC29403.1; AAH12952.1 

Protein Name

 Integral membrane protein 2C 

Protein Synonyms/Alias

 Transmembrane protein BRI3; CT-BRI3 

Gene Name

 Itm2c 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MVKISFQPAV	ubiquitination	[1]
14	QPAVAGIKADKADKA	ubiquitination	[1]
17	VAGIKADKADKAAAS	ubiquitination	[1]
20	IKADKADKAAASGPA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. 

Sequence Annotation

 DOMAIN 138 232 BRICHOS.
 MOD_RES 39 39 Phosphothreonine.
 CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Lysosome; Membrane; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IDA:MGI.
 GO:0001540; F:beta-amyloid binding; IEA:Compara.
 GO:0010977; P:negative regulation of neuron projection development; IEA:Compara.
 GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB. 

Interpro

 IPR007084; BRICHOS_dom. 

Pfam

 PF04089; BRICHOS 

SMART

 SM01039; BRICHOS 

PROSITE

 PS50869; BRICHOS 

PRINTS