CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020958
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium-dependent phosphate transport protein 2B 
Protein Synonyms/Alias
 Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Sodium/phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi-2b; Solute carrier family 34 member 2 
Gene Name
 Slc34a2 
Gene Synonyms/Alias
 Npt2b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
31PQSSIPAKDKEASKTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. 
Sequence Annotation
 CARBOHYD 295 295 N-linked (GlcNAc...) (Potential).
 CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
 CARBOHYD 321 321 N-linked (GlcNAc...) (Potential).
 CARBOHYD 356 356 N-linked (GlcNAc...) (Potential).
 DISULFID 303 350 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 697 AA 
Protein Sequence
MAPWPELENA QPNPGKFIEG ASGPQSSIPA KDKEASKTND NGTPVAKTEL LPSYSALVLI 60
EEHPEGTDPW DLPELQDTGI KWSERDTKGK TLCIFQGVGK FILLLGFLYL FVCSLDVLSS 120
AFQLVGGKVA GQFFSNNSIM SNPVAGLVIG VLVTVMVQSS STSSSIIVSM VASSLLTVRA 180
AIPIIMGANI GTSITNTIVA LMQAGDRNEF RRAFAGATVH DFFNWLSVFV LLPLEAATHY 240
LEILTNLVLE TFKFQNGEDA PDILKVITDP FTKLIIQLDK KVIQQIAMGD SAAQNKSLIK 300
IWCKSITNVT EMNVTVPSTD NCTSPSYCWT DGIQTWTIQN VTQKENIAKC QHIFVNFSLP 360
DLAVGIILLT VSLVVLCGCL IMIVKLLGSV LRGQVATVIK KTLNTDFPFP FAWLTGYLAI 420
LVGAGMTFIV QSSSVFTSAM TPLIGIGVIS IERAYPLTLG SNIGTTTTAI LAALASPGNT 480
LRSSLQIALC HFFFNISGIL LWYPIPFTRL PIRLAKGLGN ISAKYRWFAV FYLIFFFFVT 540
PLTVFGLSLA GWPVLVGVGV PIILLLLLVL CLRMLQFRCP RILPLKLRDW NFLPLWMHSL 600
KPWDNVISLA TTCFQRRCCC CCRVCCRVCC MVCGCKCCRC SKCCRDQGEE EEEKEQDIPV 660
KASGAFDNAA MSKECQDEGK GQVEVLSMKA LSNTTVF 697 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005903; C:brush border; IDA:MGI.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042301; F:phosphate ion binding; IEA:Compara.
 GO:0031402; F:sodium ion binding; IEA:Compara.
 GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; IDA:MGI.
 GO:0005436; F:sodium:phosphate symporter activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0030643; P:cellular phosphate ion homeostasis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0009750; P:response to fructose stimulus; IEA:Compara. 
Interpro
 IPR003841; Na/Pi_transpt. 
Pfam
 PF02690; Na_Pi_cotrans 
SMART
  
PROSITE
  
PRINTS