| Tag | Content |
|---|
| CPLM ID | CPLM-011227 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transducin-like enhancer protein 3 |
Protein Synonyms/Alias | Enhancer of split groucho-like protein 3; ESG3 |
Gene Name | TLE3 |
Gene Synonyms/Alias | KIAA1547 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 30 | AESCDRIKDEFQFLQ | ubiquitination | [1, 2] | | 343 | GLRSMPGKPPGMDPI | ubiquitination | [1, 2] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). |
Sequence Annotation | REPEAT 484 522 WD 1.
REPEAT 530 569 WD 2.
REPEAT 574 613 WD 3.
REPEAT 616 655 WD 4.
REPEAT 657 696 WD 5.
REPEAT 698 737 WD 6.
REPEAT 739 771 WD 7.
REGION 199 268 CCN domain.
MOTIF 225 228 Nuclear localization signal (Potential).
MOD_RES 203 203 Phosphoserine.
MOD_RES 207 207 Phosphoserine.
MOD_RES 217 217 Phosphoserine.
MOD_RES 240 240 Phosphoserine.
MOD_RES 245 245 Phosphoserine.
MOD_RES 259 259 Phosphothreonine.
MOD_RES 263 263 Phosphoserine.
MOD_RES 267 267 Phosphoserine.
MOD_RES 286 286 Phosphoserine.
MOD_RES 312 312 Phosphothreonine.
MOD_RES 317 317 Phosphoserine.
MOD_RES 319 319 Phosphothreonine.
MOD_RES 321 321 Phosphothreonine.
MOD_RES 328 328 Phosphothreonine.
MOD_RES 334 334 Phosphothreonine.
MOD_RES 413 413 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 772 AA |
Protein Sequence | MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 120
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 180
KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 240
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 300
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI GIMASALRTP 360
ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS AAAAAAAAAY GRSPMVSFGA 420
VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF HVSADGQMQP VPFPHDALAG PGIPRHARQI 480
NTLSHGEVVC AVTISNPTRH VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL 540
LPDGRTLIVG GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI 600
AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG RQLQQHDFTS 660
QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE SCVLSLKFAY CGKWFVSTGK 720
DNLLNAWRTP YGASIFQSKE SSSVLSCDIS ADDKYIVTGS GDKKATVYEV IY 772 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0007219; P:Notch signaling pathway; TAS:Reactome. GO:0009887; P:organ morphogenesis; TAS:ProtInc. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |