UniProt Accession

 RFC2_HUMAN; P35250; B5BU07; D3DXG3; P32846; Q9BU93 

Genbank Protein ID

 M87338; AF045555; AF483622; AC005081; AB451243; CH471200; CH471200; BC002813 

Genbank Nucleotide ID

 AAB09786.1; AAC04860.1; AAL82503.1; AAP22334.1; BAG70057.1; EAW69607.1; EAW69608.1; AAH02813.1 

Protein Name

 Replication factor C subunit 2 

Protein Synonyms/Alias

 Activator 1 40 kDa subunit; A1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40 

Gene Name

 RFC2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
99	ALLGPALKDAMLELN	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). 

Sequence Annotation

 NP_BIND 76 83 ATP (Potential).
 MOD_RES 163 163 N6-acetyllysine.
 MOD_RES 304 304 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; DNA replication; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Williams-Beuren syndrome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 354 AA 

Protein Sequence

Gene Ontology

 GO:0005663; C:DNA replication factor C complex; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005524; F:ATP binding; TAS:ProtInc.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0006297; P:nucleotide-excision repair, DNA gap filling; TAS:Reactome.
 GO:0000722; P:telomere maintenance via recombination; TAS:Reactome.
 GO:0032201; P:telomere maintenance via semi-conservative replication; TAS:Reactome.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR008921; DNA_pol3_clamp-load_cplx_C.
 IPR027417; P-loop_NTPase.
 IPR013748; Rep_factorC_C_dom. 

Pfam

 PF00004; AAA
 PF08542; Rep_fac_C 

SMART

 SM00382; AAA 

PROSITE

  

PRINTS