CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004295
UniProt Accession
Genbank Protein ID
 J05118 
Genbank Nucleotide ID
Protein Name
 Mast cell carboxypeptidase A 
Protein Synonyms/Alias
 MC-CPA; Carboxypeptidase A3 
Gene Name
 Cpa3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
124AKYNDWDKIVSWTEKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 ACT_SITE 378 378 Nucleophile (By similarity).
 METAL 176 176 Zinc (By similarity).
 METAL 179 179 Zinc (By similarity).
 METAL 304 304 Zinc (By similarity).
 DISULFID 173 186 By similarity.
 DISULFID 245 268 By similarity.  
Keyword
 Carboxypeptidase; Complete proteome; Cytoplasmic vesicle; Disulfide bond; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome; Signal; Zinc; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 417 AA 
Protein Sequence
MRFFLLMAVI YTTLAIAPVH FDREKVFRVK LQNEKHASVL KNLTQSIELD FWYPDAIHDI 60
AVNMTVDFRV SEKESQTIQS TLEQHKIHYE ILIHDLQEEI EKQFDVKDEI AGRHSYAKYN 120
DWDKIVSWTE KMLEKHPEMV SRIKIGSTVE DNPLYVLKIG KKDGERKAIF MDCGIHAREW 180
ISPAFCQWFV YQATKSYGKN KIMTKLLDRM NFYVLPVFNV DGYIWSWTQD RMWRKNRSRN 240
QNSTCIGTDL NRNFDVSWDS SPNTNKPCLN VYRGPAPESE KETKAVTNFI RSHLNSIKAY 300
ITFHSYSQML LIPYGYTFKL PPNHQDLLKV ARIATDALST RYETRYIYGP IASTIYKTSG 360
SSLDWVYDLG IKHTFAFELR DKGKSGFLLP ESRIKPTCKE TMLSVKFIAK YILKNTS 417 
Gene Ontology
 GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
 GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0002002; P:regulation of angiotensin levels in blood; IGI:MGI. 
Interpro
 IPR000834; Peptidase_M14.
 IPR003146; Prot_inh_M14A.
 IPR009020; Prot_inh_propept. 
Pfam
 PF00246; Peptidase_M14
 PF02244; Propep_M14 
SMART
 SM00631; Zn_pept 
PROSITE
 PS00132; CARBOXYPEPT_ZN_1
 PS00133; CARBOXYPEPT_ZN_2 
PRINTS
 PR00765; CRBOXYPTASEA.