CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038035
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase SIK3 
Protein Synonyms/Alias
  
Gene Name
 Sik3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
337IAECQQLKEERQSDPacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1369 AA 
Protein Sequence
MAAAAASGAG GVAVAGAGGA GPAGRLLPPP AAGPPAAPAA VPPAAVPARP TAPASRGSMA 60
ARIGYYEIDR TIGKGNFAVV KRATHLVTKA KVAIKIIDKS QLDEENLKKI FREVQIMKML 120
CHPHIIRLYQ VMETERMIYL VTEYASGGEI FDHLVAHGRM AEKEARRKFK QIVTAVYFCH 180
CRNIVHRDLK AENLLLDANL NIKIADFGFS NLFTPGQLLK TWCGSPPYAA PELFEGKEYD 240
GPKVDIWSLG VVLYVLVCGA LPFDGSTLQN LRARVLSGKF RIPFFMSTEC EHLIRHMLVL 300
DPNKRLSMEQ ICRHKWMKLG DADPNFDRLI AECQQLKEER QSDPLNDDVL LAMEDMGLDK 360
ERTLQSLRSD AYDHYSAIYS LLCDRHKKHK TLRPGALPSM PQAMTFQAPV NLQAEQTGTA 420
MNLSVPQVQL INPENQIIEP DGAVNLDSDE GEEPSPEALV RYLSMRRHTV GVADPRTEVM 480
EDLQKLLPGF PGVNPQGPFL QVAPNMNFTH NLLPMQSLQP TGQLEYKEQS LLQPPTLQLL 540
NGMGPLGRRA SDGGANIQLH AQQLLKRPRG PSPLVTMTPA VPAVTPVDEE SSDGEPDQEA 600
VQRYLANRSK RHTLAMTSPT AEIPPDLQRQ LGQQSFRSRV WPPHLVPDQH RSTYKDSNTL 660
HLPTERFSPV RRFSDGAASI QAFKAHLEKM GNSSSIKQLQ QECEQLQKMY GGQVDERTLE 720
KTQQQHMLYQ QEQHHQILQQ QIQDSICPPQ PSPPLQVACE NQPALLTHQL QRLRIQPSSP 780
PPNHPSNHLF RQPSNSPPPV SSAMITSHGA TSPSQFQGLP SHGAIFQQQP ENCSPPPSVA 840
LTCLGLQQAS QSQPVTIQLQ EPVDMLSNMA GTAAGSAGRS IPISPSASQI QIQHRASLMA 900
PFSYGHRPLS KQLSADSAEA HSLNMNRFSP ANYDQAHLHP HLFSDQSRGS PSSYSPSTGV 960
GFPPTQALKV PPLDQFPTFP PSAQQQPPHY TTSALQQALL SPTPPDYPRH QQVPHILQGL 1020
LSPRHSLTGH SDIRLPPAEF AQLIKRQQQH RQQQQQQQQQ QEYHELFRHM NQGDAVSLAP 1080
SLGGQNMTEQ QALSYQNADS YHRHHTSPQH ILQIRAQDCI SQGPSPTPTH GYAHQPPLMH 1140
SESMEEDCLC EGLKEGFPDK SSSTLTKGCH NSPLLLCTSG PGDPEPLLGT VSQARELGIH 1200
PYGHQPTATT FSRNKVPSRE SVLGNCLERS SPGQAMELPD HNGLGYPVRP LVSEHLRSRT 1260
LQRHHTIQNS DDAYVQLDTL PGMSLVAGKA LSSARMSDAV LSQSSLMGSQ QFQDEEDEEC 1320
GVSLGHEHPG LGDGSQHLNS SRYPATCVTD IMLSHKHPEV SFSMEQAGV 1369 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR015940; UBA/transl_elong_EF1B_N_euk. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50030; UBA 
PRINTS