| Tag | Content |
|---|
| CPLM ID | CPLM-004034 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 |
Protein Synonyms/Alias | HMG-CoA reductase 2 |
Gene Name | HMG2 |
Gene Synonyms/Alias | YLR450W; L9324.2 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 633 | LPLYSLEKKLEDTTR | acetylation | [1] | | 662 | SPILVSEKLPFRNYD | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | One of 2 isozymes that catalyze the conversion of HMG- CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis. |
Sequence Annotation | DOMAIN 188 356 SSD.
REGION 524 613 Linker.
REGION 614 1045 Catalytic.
ACT_SITE 710 710 Charge relay system (By similarity).
ACT_SITE 844 844 Charge relay system (By similarity).
ACT_SITE 920 920 Charge relay system (By similarity).
ACT_SITE 1016 1016 Proton donor (By similarity).
MOD_RES 565 565 Phosphothreonine.
CARBOHYD 115 115 N-linked (GlcNAc...) (Potential).
CARBOHYD 150 150 N-linked (GlcNAc...) (Potential).
CARBOHYD 158 158 N-linked (GlcNAc...) (Potential).
CARBOHYD 179 179 N-linked (GlcNAc...) (Potential).
CARBOHYD 428 428 N-linked (GlcNAc...) (Potential).
CARBOHYD 455 455 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1045 AA |
Protein Sequence | MSLPLKTIVH LVKPFACTAR FSARYPIHVI VVAVLLSAAA YLSVTQSYLN EWKLDSNQYS 60
TYLSIKPDEL FEKCTHYYRS PVSDTWKLLS SKEAADIYTP FHYYLSTISF QSKDNSTTLP 120
SLDDVIYSVD HTRYLLSEEP KIPTELVSEN GTKWRLRNNS NFILDLHNIY RNMVKQFSNK 180
TSEFDQFDLF IILAAYLTLF YTLCCLFNDM RKIGSKFWLS FSALSNSACA LYLSLYTTHS 240
LLKKPASLLS LVIGLPFIVV IIGFKHKVRL AAFSLQKFHR ISIDKKITVS NIIYEAMFQE 300
GAYLIRDYLF YISSFIGCAI YARHLPGLVN FCILSTFMLV FDLLLSATFY SAILSMKLEI 360
NIIHRSTVIR QTLEEDGVVP TTADIIYKDE TASEPHFLRS NVAIILGKAS VIGLLLLINL 420
YVFTDKLNAT ILNTVYFDST IYSLPNFINY KDIGNLSNQV IISVLPKQYY TPLKKYHQIE 480
DSVLLIIDSV SNAIRDQFIS KLLFFAFAVS ISINVYLLNA AKIHTGYMNF QPQSNKIDDL 540
VVQQKSATIE FSETRSMPAS SGLETPVTAK DIIISEEIQN NECVYALSSQ DEPIRPLSNL 600
VELMEKEQLK NMNNTEVSNL VVNGKLPLYS LEKKLEDTTR AVLVRRKALS TLAESPILVS 660
EKLPFRNYDY DRVFGACCEN VIGYMPIPVG VIGPLIIDGT SYHIPMATTE GCLVASAMRG 720
CKAINAGGGA TTVLTKDGMT RGPVVRFPTL IRSGACKIWL DSEEGQNSIK KAFNSTSRFA 780
RLQHIQTCLA GDLLFMRFRT TTGDAMGMNM ISKGVEYSLK QMVEEYGWED MEVVSVSGNY 840
CTDKKPAAIN WIEGRGKSVV AEATIPGDVV KSVLKSDVSA LVELNISKNL VGSAMAGSVG 900
GFNAHAANLV TALFLALGQD PAQNVESSNC ITLMKEVDGD LRISVSMPSI EVGTIGGGTV 960
LEPQGAMLDL LGVRGPHPTE PGANARQLAR IIACAVLAGE LSLCSALAAG HLVQSHMTHN 1020
RKTNKANELP QPSNKGPPCK TSALL 1045 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD. GO:0016021; C:integral to membrane; ISM:SGD. GO:0005635; C:nuclear envelope; IDA:SGD. GO:0034399; C:nuclear periphery; IDA:SGD. GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; ISA:SGD. GO:0050661; F:NADP binding; IEA:InterPro. GO:0015936; P:coenzyme A metabolic process; IEA:InterPro. GO:0006696; P:ergosterol biosynthetic process; ISA:SGD. GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |