CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037401
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 3-phosphoinositide-dependent protein kinase 1 
Protein Synonyms/Alias
  
Gene Name
 PDPK1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
208KVLSPESKQARANSFubiquitination[1]
230SPELLTEKSACKSSDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 529 AA 
Protein Sequence
MVRTQTESST PPGIPGGSRQ GPAMDGTAAE PRPGAGSLQH AQPPPQPRKK RPEDFKFGKI 60
LGEGSFSTVV LARELATSRE YAIKILEKRH IIKENKVPYV TRERDVMSRL DHPFFVKLYF 120
TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF DETCTRFYTA EIVSALEYLH GKGIIHRDLK 180
PENILLNEDM HIQITDFGTA KVLSPESKQA RANSFVGTAQ YVSPELLTEK SACKSSDLWA 240
LGCIIYQLVA GLPPFRAGNE YLIFQKIIKL EYDFPEKFFP KARDLVEKLL VLDATKRLGC 300
EEMEGYGPLK AHPFFESVTW ENLHQQTPPK LTAYLPAMSE DDEDCYGNYD NLLSQFGCMQ 360
VSSSSSSHSL SASDTGLPQR SGSNIEQYIH DLDSNSFELD LQFSEDEKRL LLEKQAGGNP 420
WHQFVENNLI LKMGPVDKRK GLFARRRQLL LTEGPHLYYV DPVNKVLKGE IPWSQELRPE 480
AKNFKTFFVH TPNRTYYLMD PSGNAHKWCR KIQEVWRQRY QSHPDAAVQ 529 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004676; F:3-phosphoinositide-dependent protein kinase activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0048041; P:focal adhesion assembly; IEA:Compara.
 GO:0006972; P:hyperosmotic response; IEA:Compara.
 GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Compara.
 GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IEA:Compara.
 GO:0010594; P:regulation of endothelial cell migration; IEA:Compara.
 GO:0043304; P:regulation of mast cell degranulation; IEA:Compara.
 GO:0003323; P:type B pancreatic cell development; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR011993; PH_like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS