UniProt Accession

 NENF_MOUSE; Q9CQ45; Q5TM91 

Genbank Protein ID

 AB126218; AK002413; AK004329; AK009304; AK020403; AK155319; BC048464 

Genbank Nucleotide ID

 BAD72062.1; BAB22081.1; BAB23264.1; BAB26205.1; BAB32092.1; BAE33187.1; AAH48464.1 

Protein Name

 Neudesin 

Protein Synonyms/Alias

 Neuron-derived neurotrophic factor; Secreted protein of unknown function; SPUF protein 

Gene Name

 Nenf 

Gene Synonyms/Alias

 Spuf 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
130	ALDDVFSKVYKAKYP	acetylation	[1]
135	FSKVYKAKYPIVGYT	acetylation	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme. 

Sequence Annotation

 DOMAIN 43 128 Cytochrome b5 heme-binding.
 MOD_RES 135 135 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Heme; Iron; Metal-binding; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0008083; F:growth factor activity; IDA:MGI.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI. 

Interpro

 IPR001199; Cyt_B5-like_heme/steroid-bd. 

Pfam

 PF00173; Cyt-b5 

SMART

  

PROSITE

 PS00191; CYTOCHROME_B5_1
 PS50255; CYTOCHROME_B5_2 

PRINTS