CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042168
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
1087AFAFDGFKAQRWHQGacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4898 AA 
Protein Sequence
AQNVPPDLSI CTFVLEQSLS VRALQEMLAN TVEKSEGQVD VEKWKFMMKT AQGGGHRTLL 60
YGHAILLRHS YSGMYLCCLS TSRSSTDKLA FDVGLQEDTT GEACWWTIHP ASKQRSEGEK 120
VRVGDDLILV SVSSERYLHL SYGTGSLHVD AAFQQTLWSV APISSGSEAA QGYLIGGDVL 180
RLLHGHMDEC LTVPSGEHGE EQRRTVHYEG GAVSVHARSL WRLETLRVAW SGSHIRWGQP 240
FRLRHVTTGK YLSLLEDKNL LLMDKEKADV KSTAFTFRSS KEKLDVSVRK EVDGMGTSEI 300
KYGDSVCYIQ HVDTGLWLTY QSVDVKSVRM GSIQRKAIMH HEGHMDDGLN LSRSQHEESR 360
TARVIRSTVF LFNRFIRGLD ALSKKVKVPA VDLPIESVSL SLQDLIGYFH PPDEHLEHED 420
KQNRLRALKN RQNLFQEEGM INLVLECIDR LHVYSSAAHF ADVAGREAGE AWKSILNSLY 480
ELLAALIRGN RKNCAQFSGS LDWLISRLER LEASSGILEV LHCVLVESPE ALNIIKEGHI 540
KSIISLLDKH GRNHKVLDVL CSLCVCHGVA VRSNQHLICD NLLPGRDLLL QTRLVNHVSS 600
MRPNIFLGIS EGSAQYKKWY YELMVDHTEP FVTAEATHLR VGWASTEGYS PYPGGGEEWG 660
GNGVGDDLFS YGFDGLHLWS GCIARTVSSP NQHLLKTDDV ISCCLDLSAP SISFRINGQP 720
VQGMFENFNI DGLFFPVVSF SAGIKVRFLL GGRHGEFKFL PPPGYAPCYE AVLPKEKLKV 780
EHSREYKQER TYTRDLLGPT VSLTQAAFTP IPVDTTQIVL PPHLERIREK LAENIHELWV 840
MNKIELGWQY GPVRDDNKRQ HPCLVEFSKL PEQERNYNLQ MSLETLKTLL ALGCHVGLSD 900
EHAEEKVKKM KLPKNYQLTS GYKPAPMDLS FIKLTPAQEA MVDRLAENAH NVWARDRIRQ 960
GWTYGIQQDV KNRRNPRLVP YTLLDDRTKK SNKDSLREAV RTLLGYGYNL EAPDQDHAAR 1020
AEVCSGTGER FRIFRAEKTY AVKAGRWYFE FEAVTAGDMR VGWSRPGCQP DQELGSDERA 1080
FAFDGFKAQR WHQGNEHYGR SWQAGDVVGC MVDMNEHTMM FTLNGEILLD DSGSELAFKD 1140
FDVGDGFIPA CSLGVAQVGR MNFGKDVSTL KYFTICGLQE GYEPFAVNTN RDITMWLSKR 1200
LPQFLQVPSN HEHIEVTRID GTIDSSPCLK VTQKSFGSQN SSTDLMFYRL SMPIECAEVF 1260
SKTMAGGLPG AGLFGPKNDL EDYDADSDFE VLMKTAHGHL VPDRVDKDKE ASKPEFNNHK 1320
DYAQEKPSRL KQRFLLRRTK PDYSTSHSAR LTEDVLADDR DDYDYLMQTS TYYYSVRIFP 1380
GQEPANVWVG WITSDFHQYD TGFDLDRVRT VTVTLGDEKG KVHESIKRSN CYMVCAGESM 1440
SPGQGRNNNG LEIGCVVDAA SGLLTFIANG KELSTYYQVE PSTKLFPAVF AQATSPNVFQ 1500
FELGRIKNVM PLSAGLFKSE HKNPVPQCPP RLHVQFLSHV LWSRMPNQFL KVDVSRISER 1560
QGWLVQCLDP LQFMSLHIPE ENRSVDILEL TEQEELLKFH YHTLRLYSAV CALGNHRVAH 1620
ALCSHVDEPQ LLYAIENKYM PGLLRSGYYD LLIDIHLSSY ATARLMMNNE FIVPMTEETK 1680
SITLFPDENK KHGLPGIGLS TSLRPRMQFS SPSFVSISNE CYQYSPEFPL DILKAKTMQM 1740
LTEAVKEGSL HARDPVGGTT EFLFVPLIKL FYTLLIMGIF HNEDLKHILQ LIEPRVFKEA 1800
ACVEEEGDVL EKELSTEDSK LEGAGEEDVK VGKAPKEGLL QMKLPEPVKL QMCLLLQYLC 1860
DCQVRHRIEA IVAFSDDFVA KLQDNQRFRY NEVMQALNMS AALTARKTKE FRSPPQEQIN 1920
MLLNFKDDKS ECPCPEEIRD QLLDFHEDLM THCGIELDED GSLDGNSDLT IRGRLLSLVE 1980
KVTYLKKKQS EKPVASDAKK SSSLQQLISE TMVRWAQESI IEDPELVRAM FVLLHRQYDG 2040
IGGLVRALPK TYTINGVSVE DTINLLASLG QIRSLLSVRM GKEEEKLMIR GLGDIMNNKV 2100
FYQHPNLMRA LGMHETVMEV MVNVLGGGES KNITFEKMHF SILNFKMYFS HYGIKSIIIH 2160
INPILHNLSL ESASPAMRGS TPLDVAAASV MDNNELALAL REPDLEKVVR YLAGCGLQSC 2220
QMLVSKGYPD IGWNPVEGER YLDFLRFAVF CNGESVEENA NVVVRLLIRR PECFGPALRG 2280
EGGNGLLAAM EEAIKIAEDP SRDGPSPTSG SSKTLDTEEE EDDTIHMGNA IMTFYAALID 2340
LLGRCAPEMH LIHAGKGEAI RIRSILRSLI PLGDLVGVIS IAFQMPTIAK DGNVVEPDMS 2400
AGFCPDHKAA MVLFLDRVYG IEVQDFLLHL LEVGFLPDLR AAASLDTAAL SATDMALALN 2460
RYLCTAVLPL LTRCAPLFAG TEHHASLIDS LLHTVYRLSK GCSLTKAQRD SIEVCLLSIC 2520
GQLRPSMMQH LLRRLVFDVP LLNEHAKMPL KLLTNHYERC WKYYCLPGGW GNFGAASEEE 2580
LHLSRKLFWG IFDALSQKKY EQELFKLALP CLSAVAGALP PDYMESNYVS MMEKQSSMDS 2640
EGNFNPQPVD TSNITIPEKL EYFINKYAEH SHDKWSMDKL ANGWIYGEIY SDSSKIQPLM 2700
KPYKLLSEKE KEIYRWPIKE SLKTMLAWGW RIERTREGDS MALYNRTRRI SQTSQVSVDA 2760
AHGYSPRAID MSNVTLSRDL HAMAEMMAEN YHNIWAKKKK LELESKGGGN HPLLVPYDTL 2820
TAKEKAKDRE KAQDILKFLQ INGYAVSRRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA 2880
HQYILEFDGG SRSKGEHFPY EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA 2940
SNKEKEMVTS LFCKLGVLVR HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA 3000
LRAFLDNAAE DLENTMENLK QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ 3060
FGEDLILEDV QVSCYRILTS LYALGTSKSI YVERQRSALG ECLAAFAGAF PVAFLETHLD 3120
KHNVHSIYNT KSSRERAALN LPPNVEDVCP NIPSLEKLME EIVELAESGI RYTQMPHVME 3180
VVLPMLCSYM SRWWEHGPEN NPERSEMCCT ALNSEHMNTL LGNILKIIYN NLGIDEGAWM 3240
KRLAVFSQPI INKVKPQLLK THFLPLMEKL KKKAAMVVAE EDHLKAEARG DMSEAELLIL 3300
DEFTTLARDL YAFYPLLIRF VDYNRAKWLK EPNPEAEELF RMVAEVFIYW SKSHNFKREE 3360
QNFVVQNEIN NMSFLITDTK SKMSKAAVSD QERKKMKRKG DRYSMQTSLI VAALKRLLPI 3420
GLNICAPGDQ ELIALAKNRF SLKDTEDEVR DIIRSNIHLQ GKLEDPAIRW QMALYKDLPN 3480
RTEDTSDPER TVERVLDIAN VLFHLEQKSK CIGRRYYNLV EHPQRSKKAV WHKLLSKQRK 3540
RAVVACFRMA PLYNLPRHRA VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAKPPEEDE 3600
AAKRVDPLHQ LILLFSRTAL TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE 3660
KEMEKQKLLY QQARLHDRGA AEMVLQTISA SKGETGPMVA ATLKLGIAIL NGGNSTVQQK 3720
MLDYLKEKKD VGFFQSLAGL MQSCSVLDLN AFERQNKAEG LGMVTEEGSG EKVLQDDEFT 3780
CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT TVNIIISTVD YLLRVQESIS DFYWYYSGKD 3840
VIDEQGQRNF SKAIQVAKQV FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM 3900
KLSQDSSQIE LLKELMDLQK DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF 3960
FDMFLKLKDL TSSDTFKEYD PDGKGVISKR DFHKAMESHK HYTQSETEFL LSCAETDENE 4020
TLDYEEFVKR FHEPAKDIGF NVAVLLTNLS EHMPNDTRLQ TFLELAESVL NYFQPFLGRI 4080
EIMGSAKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT 4140
IFEMQLAAQI SESDLNERST NKEESEKERL EEQGPRMGFF SILTVRSALL ALRYNILTLM 4200
RMLSLKSLTM KDMVTAFFSS YWSVFVTLLH FVASVCRGFF RIVCSLLLGG SLVEGAKKIK 4260
VAELLANMPD PTQDEVRGDG EEGERKPMET PLPSEDLTDL KELAEESDLL SDIFGLDLKR 4320
EGGQYKLIPH NPNAGLGDLM SNPVPIPEVQ EKFQERSGFL LNKEHKLTLK SEPEKAEGED 4380
GEKEEKAKED KGKQKLRQLH THRYGEPEVP ESAFWKKIIA YQQKLLNYFA RNFYNMRMLA 4440
LFVAFAINFI LLFYKVSTAS VAEGKELPTR SPSESAKVTT SLDSSSHRII AVHYVLEESS 4500
GYMEPTLRIL AILHTVISFF CIIGYYCLKV PLVIFKREKE VARKLEFDGL YITEQPSEDD 4560
IKGQWDRLVI NTQSFPNNYW DKFVKRKVMD KYGEFYGRDR ISELLGMDKA ALDFSDAREK 4620
KKPKKDSSLS AVLNSIDVKY QMWKLGVVFT DNSFLYLAWY MTMSVLGHYN TAHLLDIAMG 4680
FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDG DTPDMKCDDM 4740
LTCYMFHMYV GVRAGGGIGD EIEDPAGDEY EIYRIIFDIT FFFFVIVILL AIIQGLIIDA 4800
FGELRDQQEQ VKEDMETKCF ICGIGNDYFD TVPHGFETHT LQEHNLANYL FFLMYLINKD 4860
ETEHTGQESY VWKMYQERCW EFFPAGDCFR KQYEDQLN 4898 
Gene Ontology
 GO:0034704; C:calcium channel complex; IEA:Compara.
 GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Compara.
 GO:0043924; F:suramin binding; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0003300; P:cardiac muscle hypertrophy; IEA:Compara.
 GO:0071313; P:cellular response to caffeine; IEA:Compara.
 GO:0005513; P:detection of calcium ion; IEA:Compara.
 GO:0003143; P:embryonic heart tube morphogenesis; IEA:Compara.
 GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Compara.
 GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0010460; P:positive regulation of heart rate; IEA:Compara.
 GO:0086094; P:positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction; IEA:Compara.
 GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Compara.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Compara.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IEA:Compara.
 GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0051775; P:response to redox state; IEA:Compara. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR000699; Ca-rel_channel.
 IPR008985; ConA-like_lec_gl_sf.
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR014821; Ins145_P3_rcpt.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR013333; Ryan_recept.
 IPR003032; Ryanodine_rcpt.
 IPR015925; Ryanodine_recept-rel.
 IPR009460; Ryanrecept_TM4-6.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF06459; RR_TM4-6
 PF01365; RYDR_ITPR
 PF02026; RyR
 PF00622; SPRY 
SMART
 SM00054; EFh
 SM00472; MIR
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50222; EF_HAND_2
 PS50919; MIR 
PRINTS
 PR00795; RYANODINER.