CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock 70 kDa protein 4L 
Protein Synonyms/Alias
 Heat shock 70-related protein APG-1; Osmotic stress protein 94 
Gene Name
 Hspa4l 
Gene Synonyms/Alias
 Apg1; Hsp4l; Osp94 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
93RLPYELQKMPNGSTGubiquitination[1]
194DLPSLDEKPRNVVFIubiquitination[1]
221AFNKGKLKVLATTFDubiquitination[1]
322ARVEPPLKSVMDQANubiquitination[1]
351ATRIPAVKEQVTRFFubiquitination[1]
578TIKKGKIKSIDLPIQubiquitination[1]
634YVYDFRDKLGTVYEKubiquitination[1]
641KLGTVYEKFITPEDMubiquitination[1]
757SKMNAQNKLSLTQDPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity). 
Sequence Annotation
 MOD_RES 74 74 Phosphoserine.
 MOD_RES 761 761 Phosphothreonine.  
Keyword
 Alternative splicing; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 838 AA 
Protein Sequence
MSVVGIDLGF LNCYIAVARS GGIETIANEY SDRCTPACIS LGSRTRAIGN AAKSQIVTNV 60
RNTIHGFKKL HGRSFDDPIV QTERIRLPYE LQKMPNGSTG VKVRYLEEER PFAIEQVTGM 120
LLAKLKETSE NALKKPVADC VISIPSFFTD AERRSVMAAA QVAGLNCLRL MNETTAVALA 180
YGIYKQDLPS LDEKPRNVVF IDMGHSAYQV SVCAFNKGKL KVLATTFDPY LGGRNFDEAL 240
VDYFCDEFKT KYKINVKENS RALLRLYQEC EKLKKLMSAN ASDLPLNIEC FMNDLDVSSK 300
MNRAQFEQLC ASLLARVEPP LKSVMDQANL QREDINSIEI VGGATRIPAV KEQVTRFFLK 360
DISTTLNADE AVARGCALQC AILSPAFKVR EFSITDLVPY SVTLRWKTSF EEGTGECEVF 420
SKNHPAPFSK VITFHKKEPF ELEAFYTNLH EVPYPDPRIG NFTIQNVFPQ SDGDSSKVKV 480
KVRINIHGIF SVASASVIEK QNLEGDHNDA AMETEAPKSE GKEDVDKMQV DQEEGGHQKC 540
HAEHTPEEEI DHTGAKAKAP PSDKQDRINQ TIKKGKIKSI DLPIQSSLYR QLTQDLLNSY 600
IENEGKMIMQ DKLEKERNDA KNAVEEYVYD FRDKLGTVYE KFITPEDMNK LSAMLEDTEN 660
WLYEEGEDQP KQVYVDRLQE LKKYGQPIQM KYVEHEERPK ALNDLGKKIQ LVLKVIEAHR 720
NKDERYDHLD PAEMERVEKY ISDSMNWLNS KMNAQNKLSL TQDPVVKVSE IVTKSKELDN 780
FCNPIVYKPK PKVEAPEDKA KTGSEHNGPM DGQSGSETSP DPPKGSSQHT DSGEMEVD 838 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0006457; P:protein folding; ISS:UniProtKB.
 GO:0006986; P:response to unfolded protein; ISS:UniProtKB. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.