CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034251
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peroxiredoxin-6 
Protein Synonyms/Alias
  
Gene Name
 Prdx6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
32TELGRAAKLAPEFAKubiquitination[1]
39KLAPEFAKRNVKLIAacetylation[2]
39KLAPEFAKRNVKLIAubiquitination[1]
73NGETPTEKLPFPIIDacetylation[3]
73NGETPTEKLPFPIIDubiquitination[1]
82PFPIIDDKGRDLAILacetylation[4]
82PFPIIDDKGRDLAILubiquitination[1]
117VFIFGPDKKLKLSILacetylation[4]
120FGPDKKLKLSILYPAacetylation[4]
120FGPDKKLKLSILYPAubiquitination[1]
149SLQLTGTKPVATPVDacetylation[3, 4]
149SLQLTGTKPVATPVDubiquitination[1]
158VATPVDWKKGESVMVubiquitination[1]
159ATPVDWKKGESVMVVubiquitination[1]
175TLSEEEAKQCFPKGVacetylation[4]
175TLSEEEAKQCFPKGVubiquitination[1]
185FPKGVFTKELPSGKKacetylation[2, 4, 5, 6]
185FPKGVFTKELPSGKKsuccinylation[6]
185FPKGVFTKELPSGKKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 200 AA 
Protein Sequence
MKWHLKMRWG ILFSHPRDFT PVCTTELGRA AKLAPEFAKR NVKLIALSID SVEDHLAWSK 60
DINAYNGETP TEKLPFPIID DKGRDLAILL GMLDPVEKDA NNMPVTARVV FIFGPDKKLK 120
LSILYPATTG RNFDEILRVV DSLQLTGTKP VATPVDWKKG ESVMVVPTLS EEEAKQCFPK 180
GVFTKELPSG KKYLRYTPQP 200 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004601; F:peroxidase activity; IMP:MGI.
 GO:0051920; F:peroxiredoxin activity; IEA:InterPro.
 GO:0032060; P:bleb assembly; IMP:MGI.
 GO:0000302; P:response to reactive oxygen species; IMP:MGI. 
Interpro
 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR019479; Peroxiredoxin_C.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF10417; 1-cysPrx_C
 PF00578; AhpC-TSA 
SMART
  
PROSITE
 PS51352; THIOREDOXIN_2 
PRINTS