CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040122
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Short-chain-specific acyl-CoA dehydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Acads 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
65LYLGPILKFGSAQQKacetylation[1, 2, 3, 4]
65LYLGPILKFGSAQQKsuccinylation[3]
72KFGSAQQKQQWITPFacetylation[1, 2, 4]
84TPFTNGDKIGCFALSacetylation[4]
144TDRSRQNKGISAFLVacetylation[1, 2]
162TPGLTLGKKEDKLGIacetylation[2]
186FEDCRIPKENLLGEPacetylation[5]
225TWRAAMLKDNKKPFTacetylation[3]
225TWRAAMLKDNKKPFTsuccinylation[3]
228AAMLKDNKKPFTKESacetylation[4]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 302 AA 
Protein Sequence
XFPTAQVKKM GELGLLAMDV PEELSGAGLD YLAYSIALEE ISRACASTGV IMSVNNSLYL 60
GPILKFGSAQ QKQQWITPFT NGDKIGCFAL SEPGNGSDAG AASTTAREEG DSWVLNGTKA 120
WITNSWEASA TVVFASTDRS RQNKGISAFL VPMPTPGLTL GKKEDKLGIR ASSTANLIFE 180
DCRIPKENLL GEPGMGFKIA MFKLADMALA LESARLLTWR AAMLKDNKKP FTKESAMAKL 240
AASEAATAIS HQAIQILGGM GYVTEMPAER YYRDARITEI YEGTSEIQRL VIAGHLLRSY 300
RS 302 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. 
Interpro
 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 
Pfam
 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 
SMART
  
PROSITE
 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 
PRINTS