CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036943
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Syntaxin-binding protein 2 
Protein Synonyms/Alias
  
Gene Name
 STXBP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MAPSGLKAVVGEKIubiquitination[1]
13LKAVVGEKILSGVIRubiquitination[1, 2, 3, 4, 5, 6]
63TIVEDINKRREPIPSubiquitination[1]
100QSVQALIKDFQGTPTubiquitination[1, 2, 6]
204YPAIRYRKGPEDTAQubiquitination[1, 3, 5]
219LAHAVLAKLNAFKADubiquitination[1, 2, 3, 5, 6]
224LAKLNAFKADTPSLGubiquitination[1, 3, 5]
236SLGEGPEKTRSQLLIubiquitination[1, 3, 6]
312MHIADVSKKVTELLRubiquitination[1]
313HIADVSKKVTELLRTubiquitination[1]
331SKRLTTDKANIKDLSubiquitination[1, 2, 6]
335TTDKANIKDLSQILKubiquitination[1, 2, 3, 5]
342KDLSQILKKMPQYQKubiquitination[1]
343DLSQILKKMPQYQKEubiquitination[1]
414AAVPAYDKIRVLLLYubiquitination[1]
491SRWTPVIKDVMEDAVubiquitination[1, 3]
571VTRATEGKWEVLIGSubiquitination[1, 2, 5]
592TRFLDDLKALDKKLEubiquitination[1, 3, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 604 AA 
Protein Sequence
MAPSGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED 60
INKRREPIPS LEAIYLLSPT EKAQAQRVIH LPQSVQALIK DFQGTPTFTY KAAHIFFTDT 120
CPEPLFSELG RSRLAKVVKT LKEIHLAFLP YEAQVFSLDA PHSTYNLYCP FRAEERTRQL 180
EVLAQQIATL CATLQEYPAI RYRKGPEDTA QLAHAVLAKL NAFKADTPSL GEGPEKTRSQ 240
LLIMDRAADP VSPLLHELTF QAMAYDLLDI EQDTYRYETT GLSEAREKAV LLDEDDDLWV 300
ELRHMHIADV SKKVTELLRT FCESKRLTTD KANIKDLSQI LKKMPQYQKE LNKYSTHLHL 360
ADDCMKHFKG SVEKLCSVEQ DLAMGSDAEG EKIKDSMKLI VPVLLDAAVP AYDKIRVLLL 420
YILLRNGVSE ENLAKLIQHA NVQAHSSLIR NLEQLGGTVT NPGGSGTSSR LEPRERMEPT 480
YQLSRWTPVI KDVMEDAVED RLDRNLWPFV SDPAPTASSQ AAVSARFGHW HKNKAGIEAR 540
AGPRLIVYVM GGVAMSEMRA AYEVTRATEG KWEVLIGSSH ILTPTRFLDD LKALDKKLED 600
IALP 604 
Gene Ontology
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS