| Tag | Content |
|---|
| CPLM ID | CPLM-011403 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial |
Protein Synonyms/Alias | PDHE1-A type II |
Gene Name | Pdha2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 64 | LTREEALKYYRNMQV | acetylation | [1] | | 133 | YTRGLSVKSILAELT | acetylation | [1] | | 314 | EVQNVRSKSDPIMLL | acetylation | [1] | | 337 | LSSVEELKEIDADVK | acetylation | [1] | | 344 | KEIDADVKKEVEEAA | acetylation | [1] | | 383 | FEVRGAHKWLKFKSV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. |
Sequence Annotation | MOD_RES 294 294 Phosphoserine; by PDK1, PDK2, PDK3 and
MOD_RES 301 301 Phosphoserine; by PDK3 (By similarity). |
Keyword | Carbohydrate metabolism; Complete proteome; Glucose metabolism; Mitochondrion; Oxidoreductase; Phosphoprotein; Pyruvate; Reference proteome; Thiamine pyrophosphate; Transit peptide; Tricarboxylic acid cycle. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 391 AA |
Protein Sequence | MRKMLATVLS QVFSGMVQKP ALRGLLSSLK FSNDATCDIK KCDLYLLEQG PPTSTVLTRE 60
EALKYYRNMQ VIRRMELKAD QLYKQKFIRG FCHLCDGQEA CNVGLEAGIN PTDHIITSYR 120
AHGLCYTRGL SVKSILAELT GRKGGCAKGK GGSMHMYAKN FYGGNGIVGA QVPLGAGVAL 180
ACKYLKNGQI CLALYGDGAA NQGQVFEAYN MSALWKLPCV FICENNRYGM GTAIERSAAS 240
TDYHKKGFVI PGLRVNGMDI LSVREATKFA ADHCRSGKGP IVMELQTYRY HGHSMSDPGI 300
SYRTREEVQN VRSKSDPIML LRERMISNNL SSVEELKEID ADVKKEVEEA AQFATTDPEP 360
PLEDLANYLY HQNPPFEVRG AHKWLKFKSV S 391 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:RGD. GO:0045254; C:pyruvate dehydrogenase complex; IDA:RGD. GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IDA:RGD. GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:RGD. GO:0006096; P:glycolysis; IEA:InterPro. GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |