| Tag | Content |
|---|
| CPLM ID | CPLM-011567 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protocadherin-1 |
Protein Synonyms/Alias | Cadherin-like protein 1; Protocadherin-42; PC42 |
Gene Name | PCDH1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 900 | TKDLYAPKPSGKASK | ubiquitination | [1] | | 923 | SKSPKPVKPVEDEDE | ubiquitination | [1] | | 935 | EDEAGLQKSLKFNLM | ubiquitination | [1] | | 938 | AGLQKSLKFNLMSDA | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May be involved in cell-cell interaction processes and in cell adhesion. |
Sequence Annotation | DOMAIN 58 168 Cadherin 1.
DOMAIN 169 280 Cadherin 2.
DOMAIN 281 387 Cadherin 3.
DOMAIN 396 506 Cadherin 4.
DOMAIN 507 612 Cadherin 5.
DOMAIN 613 715 Cadherin 6.
DOMAIN 718 844 Cadherin 7.
MOD_RES 918 918 Phosphoserine.
MOD_RES 949 949 Phosphoserine.
MOD_RES 962 962 Phosphoserine.
MOD_RES 984 984 Phosphoserine.
CARBOHYD 305 305 N-linked (GlcNAc...).
CARBOHYD 403 403 N-linked (GlcNAc...) (Potential).
CARBOHYD 618 618 N-linked (GlcNAc...) (Potential).
CARBOHYD 662 662 N-linked (GlcNAc...) (Potential).
CARBOHYD 813 813 N-linked (GlcNAc...).
CARBOHYD 818 818 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Calcium; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1060 AA |
Protein Sequence | MDSGAGGRRC PEAALLILGP PRMEHLRHSP GPGGQRLLLP SMLLALLLLL APSPGHATRV 60
VYKVPEEQPP NTLIGSLAAD YGFPDVGHLY KLEVGAPYLR VDGKTGDIFT TETSIDREGL 120
RECQNQLPGD PCILEFEVSI TDLVQNGSPR LLEGQIEVQD INDNTPNFAS PVITLAIPEN 180
TNIGSLFPIP LASDRDAGPN GVASYELQAG PEAQELFGLQ VAEDQEEKQP QLIVMGNLDR 240
ERWDSYDLTI KVQDGGSPPR ASSALLRVTV LDTNDNAPKF ERPSYEAELS ENSPIGHSVI 300
QVKANDSDQG ANAEIEYTFH QAPEVVRRLL RLDRNTGLIT VQGPVDREDL STLRFSVLAK 360
DRGTNPKSAR AQVVVTVKDM NDNAPTIEIR GIGLVTHQDG MANISEDVAE ETAVALVQVS 420
DRDEGENAAV TCVVAGDVPF QLRQASETGS DSKKKYFLQT TTPLDYEKVK DYTIEIVAVD 480
SGNPPLSSTN SLKVQVVDVN DNAPVFTQSV TEVAFPENNK PGEVIAEITA SDADSGSNAE 540
LVYSLEPEPA AKGLFTISPE TGEIQVKTSL DREQRESYEL KVVAADRGSP SLQGTATVLV 600
NVLDCNDNDP KFMLSGYNFS VMENMPALSP VGMVTVIDGD KGENAQVQLS VEQDNGDFVI 660
QNGTGTILSS LSFDREQQST YTFQLKAVDG GVPPRSAYVG VTINVLDEND NAPYITAPSN 720
TSHKLLTPQT RLGETVSQVA AEDFDSGVNA ELIYSIAGGN PYGLFQIGSH SGAITLEKEI 780
ERRHHGLHRL VVKVSDRGKP PRYGTALVHL YVNETLANRT LLETLLGHSL DTPLDIDIAG 840
DPEYERSKQR GNILFGVVAG VVAVALLIAL AVLVRYCRQR EAKSGYQAGK KETKDLYAPK 900
PSGKASKGNK SKGKKSKSPK PVKPVEDEDE AGLQKSLKFN LMSDAPGDSP RIHLPLNYPP 960
GSPDLGRHYR SNSPLPSIQL QPQSPSASKK HQVVQDLPPA NTFVGTGDTT STGSEQYSDY 1020
SYRTNPPKYP SKQLPHRRVT FSATSQAQEL QDPSQHSYYD SGLEESETPS SKSSSGPRLG 1080
PLALPEDHYE RTTPDGSIGE MEHPENDLRP LPDVAMTGTC TRECSEFGHS DTCWMPGQSS 1140
PSRRTKSSAL KLSTFVPYQD RGGQEPAGAG SPSPPEDRNT KTAPVRLLPS YSAFSHSSHD 1200
SCKDSATLEE IPLTQTSDFP PAATPASAQT AKREIYL 1237 |
Gene Ontology | GO:0005911; C:cell-cell junction; TAS:ProtInc. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0007267; P:cell-cell signaling; TAS:ProtInc. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. GO:0007399; P:nervous system development; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |